The currently available data do not support a negative association between levetiracetam and bone health. Two studies suggest there may be an effect on bone strength and BMD. However, one of these studies was an animal study and one was a retrospective study, which had a limited sample size and did not control for potential confounders. The recently published report by Koo and colleagues adds to the literature as this was a well-designed longitudinal study in drug-naïve persons. Subjects were, however, followed for only a limited time. Well-powered prospective studies in individuals on levetiracetam monotherapy followed for more prolonged periods should be conducted.
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