...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>ESC Heart Failure >Persistent high blood urea nitrogen level is associated with increased risk of cardiovascular events in patients with acute heart failure
【24h】

Persistent high blood urea nitrogen level is associated with increased risk of cardiovascular events in patients with acute heart failure

机译：持久性高血尿素氮水平与急性心力衰竭患者发生心血管事件的风险增加相关

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Aims The association between kinetics of blood urea nitrogen (BUN) levels in hospital and cardiovascular outcomes in patients with acutely decompensated congestive heart failure (HF) is unclear. We aimed to estimate the impact of changes in BUN level during hospitalization on clinical prognosis in patients with acute HF. Methods and results A total of 353 consecutive patients that were urgently hospitalized due to acutely decompensated HF and discharged alive were divided into four subgroups depending on their BUN level at admission and discharge, using a cut-off level of 21.0 mg/dL. Among 206 patients with high baseline BUN level, 46 (22%) and 160 (78%) had normal and persistent high BUN levels at discharge, respectively. In contrast, of the 147 patients with normal baseline BUN level, 55 (37%) and 92 (63%) had high and normal BUN levels at discharge, respectively. During the observational period after discharge, Kaplan?￠????Meier analysis showed the highest rate of combined outcome of cardiovascular death and HF readmission in patients with persistent high BUN (log-rank test: P < 0.001). After adjustment for comorbidities, the hazard ratio for a combined outcome was significantly lower in patients with normalized BUN level compared with those with persistent high BUN (hazard ratio 0.48, 95% confidence interval 0.23?￠????0.99, P = 0.049). Conclusions Persistent high BUN levels in hospital are associated with an increased risk of cardiovascular death and HF readmission. Normalization of BUN levels during hospitalization may be associated with long-term clinical outcomes.
机译：摘要目的尚无急性代偿性充血性心力衰竭（HF）患者的医院血尿素氮（BUN）动力学与心血管预后之间的关联尚不清楚。我们旨在评估住院期间BUN水平变化对急性HF患者临床预后的影响。方法和结果根据入院和出院时的BUN水平，将353例因急性失代偿性HF紧急住院治疗并活着出院的连续患者分为4个亚组，截止水平为21.0 mg / dL。在206名基线BUN水平高的患者中，出院时分别有46名（22％）和160名（78％）的BUN水平正常和持续高。相反，在147名基线BUN水平正常的患者中，出院时分别有55名（37％）和92名（63％）的BUN高和正常。在出院后的观察期内，Kaplan-Meier分析显示持续高BUN患者的心血管死亡和HF再入院合并结果率最高（对数秩检验：P <0.001）。校正合并症后，与持续高BUN的患者相比，BUN正常化患者的合并结局风险比显着降低（风险比0.48，95％置信区间0.23≤0.99，P = 0.049） 。结论医院中持续的BUN高水平与心血管死亡和HF再入院的风险增加有关。住院期间BUN水平的正常化可能与长期临床结果有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号