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首页> 外文期刊>Epilepsy currents >“Please Release Me, Let Me Go”—Changes in Presynaptic Release Following Status Epilepticus
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“Please Release Me, Let Me Go”—Changes in Presynaptic Release Following Status Epilepticus

机译：“请释放我，让我走” —癫痫持续状态后突触释放的变化

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These results add another dimension to the anatomic and physiologic basis of hippocampal hyperexcitability underlying limbic epilepsy. In addition to the increased excitatory circuit activity engendered by mossy fiber sprouting and changes in intrinsic excitability of dentate granule cells, hilar neurons, and CA3 pyramidal neurons, this study provides strong evidence for altered presynaptic release mechanisms as well. It seems that the post–status epilepticus hippocampus is impaired both coming and going—from both the presynaptic side and the postsynaptic side. The epileptic animal might well have changed its tune to “please release me…and let me seize again”! Yet, with every challenge comes an opportunity, and with this additional target, it might be possible to develop therapeutic interventions that compensate for the presynaptic pathophysiology.
机译：这些结果为边缘性癫痫发作海马过度兴奋的解剖学和生理学基础增加了另一个维度。除了苔藓纤维发芽引起的兴奋性回路活动增加以及齿状颗粒细胞，肺门神经元和CA3锥体神经元固有兴奋性的改变外，这项研究还为突触前释放机制改变提供了有力的证据。似乎从突触前侧和突触后侧，来回状态的癫痫后海马都受到损害。癫痫病的动物可能已经改变了自己的调子，“请释放我……让我再次抓住”！然而，每一个挑战都会带来机会，有了这个额外的目标，就有可能开发出能够补偿突触前病理生理学的治疗性干预措施。

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