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Serotonin and Epilepsy: The Story Continues

机译：5-羟色胺和癫痫：故事还在继续

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Finally, the observations of Martinez and colleagues also prompts one to ask whether it is entirely appropriate to consider depression simply a comorbid finding in patients with epilepsy. As it is commonly defined, comorbidity refers to the presence of more than one diagnosis occurring at the same time in a given patient. This implies a distinct clinical disorder occurring during the course of the “index” disease. This might be imprecise, if not frankly inaccurate, in this patient population. Given the observed bidirectionality of epilepsy and depression, common neurochemical markers, and perhaps compensatory neurotransmitter adaptations, it is perhaps more correct to view epilepsy and depression as different expressions of a single disorder. Clearly, TLE is a heterogeneous disorder. Perhaps patients with TLE and significant mood disturbance represent a subgroup of patients with a unique neurochemical signature. These observations take us one step closer to understanding the mechanistic underpinnings of this common debilitating “comorbidity” and, perhaps, to designing personalized screening and treatment approaches.
机译：最后，马丁内斯及其同事的观察结果还提示人们要问，仅将抑郁症视为癫痫患者的一种合并症是否完全合适。正如通常定义的，合并症是指在给定的患者中同时存在多个诊断。这意味着在“指数”疾病过程中会发生明显的临床疾病。如果不是坦率地说，在这个患者人群中这可能是不精确的。鉴于观察到的癫痫和抑郁症的双向性，常见的神经化学标记物，以及可能的代偿性神经递质适应性，将癫痫病和抑郁症视为单一疾病的不同表达可能更为正确。显然，TLE是一种异质性疾病。 TLE和严重情绪障碍患者可能代表具有独特神经化学特征的患者亚组。这些观察使我们更加了解这种常见的使人衰弱的“合并症”的机制基础，也许还可以设计个性化的筛查和治疗方法。

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