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首页> 外文期刊>ESC Heart Failure >Characteristics of patients with haematological and breast cancer (1996?￠????2009) who died of heart failure-related causes after cancer therapy
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Characteristics of patients with haematological and breast cancer (1996?￠????2009) who died of heart failure-related causes after cancer therapy

机译：癌症治疗后因心力衰竭相关原因死亡的血液和乳腺癌患者的特征（1996年至2009年）

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Abstract Aims To describe the characteristics and time to death of patients with breast or haematological cancer who died of heart failure (HF) after cancer therapy. Patients with an index admission for HF who died of HF-related causes (IAHF) and those with no index admission for HF who died of HF-related causes (NIAHF) were compared. Methods and results We performed a linked data analysis of cancer registry, death registry, and hospital administration records ( n = 15 987). Index HF admission must have occurred after cancer diagnosis. Of the 4894 patients who were deceased (30.6% of cohort), 734 died of HF-related causes (50.1% female) of which 279 (38.0%) had at least one IAHF (41.9% female) post-cancer diagnosis. Median age was 71 years [interquartile range (IQR) 62?￠????78] for IAHF and 66 years (IQR 56?￠????74) for NIAHF. There were fewer chemotherapy separations for IAHF patients (median = 4, IQR 2?￠????9) compared with NIAHF patients (median = 6, IQR 2?￠????12). Of the IAHF patients, 71% had died within 1 year of the index HF admission. There was no significant difference in HF-related mortality in IAHF patients compared with NIAHF (HR, 1.10, 95% CI, 0.94?￠????1.29, P = 0.225). Conclusions The profile of IAHF patients who died of HF-related causes after cancer treatment matched the current profile of HF in the general population (over half were aged ?￠???￥70 years). However, NIAHF were younger (62% were aged ?￠???¤69 years), female patients with breast cancer that died of HF-related causes before hospital admission for HF-related causes?￠????a group that may have been undiagnosed or undertreated until death.
机译：摘要目的描述癌症治疗后因心力衰竭（HF）死亡的乳腺癌或血液癌症患者的特征和死亡时间。比较了因HF相关原因死亡的HF患者（IAHF）和因HF相关原因死亡的HF患者（NIAHF）。方法和结果我们对癌症登记，死亡登记和医院管理记录（n = 15987）进行了链接数据分析。 HF入院必须在癌症诊断后发生。在死亡的4894名患者中（占队列的30.6％），有734人死于HF相关原因（女性占50.1％），其中279名（38.0％）至少有一项IAHF（女性占41.9％）被诊断为癌症。 IAHF的中位年龄为71岁[四分位间距（IQR）62≤78]，而NIAHF的中位年龄为66岁（IQR56≤74）。与NIAHF患者（中位数= 6，IQR 2-12）相比，IAHF患者（中位数= 4，IQR 2-9）的化学疗法分离较少。在IAHF患者中，有71％在进入HF指数的一年内死亡。与NIAHF相比，IAHF患者的HF相关死亡率无显着差异（HR，1.10、95％CI，0.94≤1.29，P = 0.225）。结论癌症治疗后因HF相关原因死亡的IAHF患者的概况与一般人群中当前的HF概况相符（一半以上年龄≥70岁）。然而，NIAHF较年轻（62％年龄≥69岁），是女性女性，因入院前因HF相关原因而死于HF相关原因。直到死亡都未被诊断或治疗不足。

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