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首页> 外文期刊>African Journal of Pharmacy and Pharmacology >Evaluation of CD4+ and CD8+ T-lymphocyte counts and serum levels of immunoglobulins in pulmonary tuberculosis (PTB) patients with or without HIV co-infection in South Eastern Nigeri
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Evaluation of CD4+ and CD8+ T-lymphocyte counts and serum levels of immunoglobulins in pulmonary tuberculosis (PTB) patients with or without HIV co-infection in South Eastern Nigeri

机译：在尼日利亚东部和南部地区患有或未患有HIV合并感染的肺结核（PTB）患者中，CD4 +和CD8 + T淋巴细胞计数以及免疫球蛋白血清水平的评估

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The prevalence and incidence of tuberculosis (TB) has risen throughout sub-Saharan Africa with increasing human immuno-deficiency virus (HIV) prevalence. TB patients were recruited from some treatment centres in South Eastern Nigeria, and a total number of 133 subjects were recruited for the study. The following parameters, namely, CD4+ and CD8+ T-cell counts,?immunoglobulin?A (IgA),?immunoglobulin?G (IgG) and?immunoglobulin?M (IgM) serum levels were determined using the cytoflow method, Dynal T8 quantitative method as well as single radial immunodiffusion (SRI), respectively. The results showed that the mean CD4+ T-cell count (mm3) (338.34 ± 36.65) and CD8+ T-cell count (mm3) (278.70 ± 27.80) of pulmonary tuberculosis (PTB) patients with HIV co-infection (PTB + HIV) patients were significantly lower than the mean, CD4+ T-cell count (mm3) (788.18 ± 58.17) and CD8+ T-cell count (mm3) (421.17 ± 30.68) of control subjects. The mean CD4+ T-cell count (mm3) (614.14 ± 58.24) and CD8+ T-cell count (mm3) (388.43 ± 32.07) of PTB patients were significantly lower than those of the control subjects. The mean CD4+ T-cell count (mm3) (388.77 ± 63.62) and CD8+ T-cell count (mm3) (564.18 ± 93.68) of HIV seropositive patients were significantly lower than CD4+ T-cell count of the control subjects, but higher than CD8+ T-cell count of the control subjects (P < 0.05). The mean IgA (mg/dl) level of in PTB patients (234.96 ± 48.00) was significantly higher than those of PTB patients with HIV seropositive (PTB + HIV) (164.01 ± 42.27). The mean IgG (mg/dl) level of PTB + HIV patients (1446.37 ± 277.32) was significantly higher than that of PTB patients (1092.18 ± 114.25). The mean IgM (mg/dl) level in HIV seropositive patients (212.08 ± 22.84) was significantly higher than that of PTB patients (156.69 ± 32.07), PTB + HIV (182.76 ± 46.77) patients and control subjects (93.58 ± 21.18) (P?
机译：在整个撒哈拉以南非洲，随着人类免疫缺陷病毒（HIV）患病率的增加，结核病（TB）的患病率和发病率均有所上升。结核患者是从尼日利亚东南部的一些治疗中心招募的，总共招募了133名受试者进行研究。使用细胞流法，Dynal T8定量法测定以下参数，即CD4 +和CD8 + T细胞计数，“免疫球蛋白” A（IgA），“免疫球蛋白” G（IgG）和“免疫球蛋白” M（IgM）血清水平。以及单次放射免疫扩散（SRI）。结果显示，HIV合并感染（PTB + HIV）的肺结核（PTB）患者的平均CD4 + T细胞计数（mm3）（338.34±36.65）和CD8 + T细胞计数（mm3）（278.70±27.80）患者明显低于对照组的平均CD4 + T细胞计数（mm3）（788.18±58.17）和CD8 + T细胞计数（mm3）（421.17±30.68）。 PTB患者的平均CD4 + T细胞计数（mm3）（614.14±58.24）和CD8 + T细胞计数（mm3）（388.43±32.07）显着低于对照组。 HIV血清阳性患者的平均CD4 + T细胞计数（mm3）（388.77±63.62）和CD8 + T细胞计数（mm3）（564.18±93.68）显着低于对照组受试者的CD4 + T细胞计数，但高于对照对象的CD8 + T细胞计数（P <0.05）。 PTB患者的平均IgA（mg / dl）水平（234.96±48.00）显着高于HIV血清阳性（PTB + HIV）的PTB患者（164.01±42.27）。 PTB + HIV患者的平均IgG（mg / dl）水平（1446.37±277.32）显着高于PTB患者（1092.18±114.25）。 HIV血清阳性患者的平均IgM（mg / dl）水平（212.08±22.84）显着高于PTB患者（156.69±32.07），PTB + HIV（182.76±46.77）患者和对照组（93.58±21.18）（ P≤0.05）。因此，很明显，有或没有HIV合并感染的PTB感染都会显着影响免疫系统反应。观察到的免疫学变化表明，PTB感染可能引起CD4 +和CD8 + T淋巴细胞计数的适度下降，而在HIV合并感染的PTB感染中，下降明显。

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