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首页> 外文期刊>Emerging microbes & infections. >Serum anti-neuraminidase antibody responses in human influenza A(H1N1)pdm09 virus infections
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Serum anti-neuraminidase antibody responses in human influenza A(H1N1)pdm09 virus infections

机译：甲型H1N1流感病毒pdm09人感染血清抗神经氨酸酶抗体反应

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Haemagglutination inhibition (HAI) antibody titres are a correlate of protection for influenza virus infection, but several studies have also demonstrated the protective role of anti-neuraminidase (anti-NA) antibodies. However, there is limited data on anti-NA antibody responses in naturally occurring human influenza. We investigated anti-NA antibody responses to pandemic N1 and seasonal N1 in 18 RT–PCR-confirmed patients with naturally acquired pandemic influenza A (H1N1) 2009 disease detected as part of a prospective community study of influenza. There were increases in neuraminidase inhibition (NAI) antibody titres to both pandemic and seasonal N1 antigens, with greater fold increases in those who had low levels of anti-pandemic N1 titres in acute sera. Of 18 patients with pandemic H1N1 infection, fourfold increases in antibody were observed by HAI in 11 (61%) patients, by anti-pandemic N1 inhibition in 13 (72%) or either in 15 of them (83%). Prior seasonal H1N1 virus infections had elicited cross-reactive anti-pandemic N1 antibody titres in some people prior to the emergence of the 2009 pandemic H1N1 virus. Antibody responses to the anti-N1 pandemic 2009 virus and cross-reactive responses to anti-seasonal N1 antibody were seen in influenza A pandemic 2009 infections. NAI antibodies can complement HAI antibody in sero-diagnosis and sero-epidemiology.
机译：血凝抑制（HAI）抗体滴度与流感病毒感染的保护作用相关，但一些研究也证明了抗神经氨酸酶（anti-NA）抗体的保护作用。然而，关于天然人流感中抗NA抗体应答的数据有限。我们调查了18位经RT–PCR确认的2009年自然获得性大流行性甲型流感（H1N1）疾病患者的抗大肠N1和季节性N1的抗NA抗体反应，作为前瞻性流感社区研究的一部分。大流行和季节性N1抗原的神经氨酸酶抑制（NAI）抗体滴度都有所增加，而在急性血清中抗大流行N1滴度较低的人群中，其增加了很多倍。在18例大流行性H1N1感染患者中，HAI在11例（61％）患者中观察到抗体增加了四倍，在13例（72％）中或15例中有一种（83％）通过抗大流行性N1抗体被观察到。在2009年大流行H1N1病毒出现之前，先前的季节性H1N1病毒感染已引起一些人的交叉反应性抗大流行N1抗体效价。在2009年甲型流感大流行感染中发现了对2009年N1大流行性流感病毒的抗体反应和对反季节N1抗体的交叉反应。 NAI抗体可以在血清学诊断和血清流行病学方面补充HAI抗体。

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