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首页> 外文期刊>Emerging microbes & infections. >Intestinal microsporidiosis in Strasbourg from 2014 to 2016: emergence of an Enterocytozoon bieneusi genotype of Asian origin
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Intestinal microsporidiosis in Strasbourg from 2014 to 2016: emergence of an Enterocytozoon bieneusi genotype of Asian origin

机译：2014年至2016年斯特拉斯堡的肠道小孢子虫病：亚洲起源的Enterocytozoon bieneusi基因型的出现

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Microsporidia cause opportunistic infections in highly immunodeficient individuals. Few studies on the epidemiology of these infections have been conducted in France. Between 2014 and 2016, we undertook a study to estimate the prevalence and circulating genotypes of this fungus-related micro-organism among the population of Strasbourg University Hospital. Samples were collected from hospitalized patients and analyzed using microscopy and molecular assays. Strains from positive subjects were sequenced for genotyping. Only 7/661 patients (1.1%) were positive for microsporidia, and the only species identified was Enterocytozoon bieneusi . Two patients presented immunodeficiency linked to AIDS, and five transplant recipients presented immunodeficiency linked to immunosuppressive therapies. Only five patients received specific antimicrosporidial treatment, but clinical outcomes were good in all cases. We identified four genotypes: A and D in patients with AIDS, and C and S9 in transplant recipients. To date, genotype S9 has been described only once. This genotype is similar to those found in farm animals in China. Because some of these animals have been introduced to Central Europe, we postulate that this genotype might be of Asian origin. Thus, genotyping microsporidial strains may be of epidemiological and clinical interest to identify potential outbreak sources depending on the infecting strains.
机译：微孢子虫在高度免疫缺陷的个体中引起机会性感染。在法国，关于这些感染的流行病学的研究很少。在2014年至2016年之间，我们进行了一项研究，以估算斯特拉斯堡大学医院人群中与真菌相关的微生物的流行率和循环基因型。从住院患者中收集样品，并使用显微镜和分子分析进行分析。对来自阳性受试者的菌株进行测序以进行基因分型。只有7/661例患者（1.1％）的微孢子虫呈阳性，唯一鉴定出的物种是小肠肠杆菌。两名患者出现与艾滋病相关的免疫缺陷，五名移植受者出现与免疫抑制疗法相关的免疫缺陷。只有五名患者接受了特定的抗微孢子虫治疗，但所有病例的临床结局均良好。我们确定了四种基因型：艾滋病患者中的A和D，移植患者中的C和S9。迄今为止，仅描述了基因型S9。该基因型与中国农场动物中发现的基因型相似。由于其中一些动物已被引入中欧，因此我们推测该基因型可能源自亚洲。因此，对微孢子菌菌株进行基因分型可能具有流行病学和临床意义，以便根据感染菌株鉴定潜在的暴发源。

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