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首页> 外文期刊>African Journal of Pharmacy and Pharmacology >Application of Ipomoea batatas starch as suspending agent in acetaminophen suspension
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Application of Ipomoea batatas starch as suspending agent in acetaminophen suspension

机译：番薯淀粉作为悬浮剂在对乙酰氨基酚悬浮液中的应用

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Natural plant mucilage has gained importance over synthetic ones because of low toxicity, low cost and good availability. The objective of the study was to search for a cheap and effective natural raw material that can serve as an alternative suspending agent in the formulation of acetaminophen suspension. The phytochemical and the physicochemical properties of the mucilage of Ipomoea batatas L. were studied. The suspending properties of mucilage extract of I. batatas L. were evaluated comparatively with that of acacia and sodium alginate using model formulations at concentrations of 5, 10, 15 and 20% w/v. The suspensions were evaluated for rheological properties, sedimentation profile and stability studies. The results showed the presence of flavonoids, saponin, protein, carbohydrate and reducing sugars. The rheological properties of suspension showed that increase in concentration increased the viscosity of suspension, while increase in temperature did not significantly increased the viscosity of suspension (p D (15% w/v potato starch) > F (10% w/v sodium alginate) > C (10% w/v potato starch) > B (5% w/v potato starch). These results indicate that mucilage from I. batatas L. in acetaminophen suspension has low sedimentation rate, medium viscosity and easily dispersible and can therefore serve as suspending agent in formulations of suspensions of sparingly soluble drugs.
机译：天然植物粘液由于其低毒性，低成本和良好的可用性而变得比合成粘液更为重要。该研究的目的是寻找一种廉价而有效的天然原料，该原料可以作为对乙酰氨基酚悬浮液的替代悬浮剂。研究了番薯（Ipomoea batatas L.）粘液的理化性质。使用浓度为5％，10％，15％和20％w / v的模型制剂，与红胶和海藻酸钠的黏液相比，比较了红景天粘液提取物的悬浮特性。对悬浮液进行流变学性质，沉降曲线和稳定性研究。结果表明存在类黄酮，皂苷，蛋白质，碳水化合物和还原糖。悬浮液的流变特性表明，浓度的增加会增加悬浮液的粘度，而温度的升高并不会显着增加悬浮液的粘度（p D（15％w / v马铃薯淀粉）> F（10％w / v海藻酸钠） ）> C（10％w / v马铃薯淀粉）> B（5％w / v马铃薯淀粉）这些结果表明，对乙酰氨基酚混悬液中来自I. batatas L.的粘液沉降速率低，中等粘度且易于分散并且可以因此在微溶药物悬浮液的制剂中用作悬浮剂。

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