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首页> 外文期刊>African Journal of Pharmacy and Pharmacology >Pharmacognostic evaluation and antisickling activity of the leaves of Peperomia pellucida (L.) HBK (Piperaceae)
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Pharmacognostic evaluation and antisickling activity of the leaves of Peperomia pellucida (L.) HBK (Piperaceae)

机译：Pepelomia pellucida（L.）HBK（Piperaceae）叶片的药理学评价和抗刺活性

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Traditional healers have been using condiments from natural sources as antisickling remedies in Southern Nigeria. This study was aimed at establishing the pharmacognostic profile and investigating the antisickling activity of the leaves of Peperomia pellucida (L.) HBK (Piperaceae). Evaluation of the fresh, powdered and anatomical sections of the leaves were carried out to determine the macromorphological, micromorphological, chemomicroscopic, numerical and phytochemical profiles. Chemical tests were employed in phytochemical investigations. Evaluation of the antisickling activity involved the inhibition of sodium metabisulphite-induced sickling of the HbSS red blood cells obtained from confirmed sickle cell patients who were not in crises. Macro and microscopical studies gave results that could serve as a basis for proper identification, collection and investigation of the leaves of P. pellucida. Phytochemical evaluation revealed the presence of alkaloids, tannins, flavonoids, saponins and cardiac glycosides. Percentage sickling inhibitions of the aqueous methanol extract of P. pellucida were significant all through the period of assay p < 0. 05 compared to normal saline. The maximum percentage inhibition of sickling exhibited by the 500 mg/ml of the extract was 57.5% at 90 min incubation. These results showed that P. pellucida has a role in the treatment of sickle cell disorders and a candidate for further investigations.
机译：在尼日利亚南部，传统的治疗师一直在使用自然来源的调味品作为抗刺痛药。这项研究的目的是建立Peperomia pellucida（L.）HBK（Piperaceae）叶片的药理学特征并研究其抗渗出活性。对叶片的新鲜，粉状和解剖切片进行评估，以确定宏观形态，微观形态，化学显微镜，数值和植物化学特征。化学测试用于植物化学研究。抗镰刀菌活性的评估涉及抑制亚硫酸氢钠诱导的HbSS红细胞的镰刀切，该镰刀是从未患病的已确认镰刀细胞患者中获得的。宏观和微观研究得出的结果可作为正确鉴定，收集和研究P. pellucida叶子的基础。植物化学评估显示存在生物碱，单宁，类黄酮，皂苷和强心苷。与生理盐水相比，在整个测定期间，P。pellucida甲醇水溶液的镰状镰刀菌抑制作用均很显着p <0. 05。在孵育90分钟时，500 mg / ml提取物对镰刀菌的最大抑制百分比为57.5％。这些结果表明，P。pellucida在镰状细胞疾病的治疗中具有作用，并且是进一步研究的候选者。

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