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首页> 外文期刊>European Cells & Materials >Investigation of orofacial stem cell niches and their innervation through microfluidic devices
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Investigation of orofacial stem cell niches and their innervation through microfluidic devices

机译：通过微流控装置研究口面干细胞生态位及其神经支配

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Stem cell-based mediated therapies represent very promising approaches for tissue regeneration and are already applied with success in clinics. These therapeutic approaches consist of the in vitro manipulation of stem cells and their consequent administration to patients as living and dynamic biological agents. Nevertheless, the deregulation of stem cells function might result in the generation of pathologies such as tumours or accelerated senescence. Moreover, different stem cells sources are needed for regeneration of specific tissues. It is thus fundamental to understand the mechanisms regulating the physiology of stem cells. Microfluidic technology can be used to mimic in vivo scenarios and allow the study of stem cell physiology at both single cell and whole stem cell niche levels.This review focuses on the potential sources of stem and progenitor cells for orofacial regeneration and the use of microfluidic technologies for the study of stem cells behaviour and stem cell niches, in the light of regenerative medicine.
机译：基于干细胞的介导疗法代表了非常有希望的组织再生方法，并且已经在临床上成功应用。这些治疗方法包括干细胞的体外操作及其作为活体和动态生物制剂对患者的给药。然而，干细胞功能的失调可能导致诸如肿瘤或加速衰老之类的病理学的产生。此外，需要不同的干细胞来源来再生特定组织。因此，了解调节干细胞生理的机制至关重要。微流控技术可用于模拟体内情况，并允许在单细胞和整个干细胞生态位水平上研究干细胞生理学。本综述着眼于口腔再生的干细胞和祖细胞的潜在来源以及微流体技术的使用根据再生医学研究干细胞行为和干细胞壁cell。

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