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Full regeneration of segmental bone defects using porous titanium implants loaded with BMP-2 containing fibrin gels

机译：使用装有BMP-2的纤维蛋白凝胶的多孔钛植入物完全再生节段性骨缺损

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Regeneration of load-bearing segmental bone defects is a major challenge in trauma and orthopaedic surgery. The ideal bone graft substitute is a biomaterial that provides immediate mechanical stability, while stimulating bone regeneration to completely bridge defects over a short period. Therefore, selective laser melted porous titanium, designed and fine-tuned to tolerate full load-bearing, was filled with a physiologically concentrated fibrin gel loaded with bone morphogenetic protein-2 (BMP-2). This biomaterial was used to graft critical-sized segmental femoral bone defects in rats. As a control, porous titanium implants were either left empty or filled with a fibrin gels without BMP-2. We evaluated bone regeneration, bone quality and mechanical strength of grafted femora using in vivo and ex vivo µCT scanning, histology, and torsion testing. This biomaterial completely regenerated and bridged the critical-sized bone defects within eight weeks. After twelve weeks, femora were anatomically re-shaped and revealed open medullary cavities. More importantly, new bone was formed throughout the entire porous titanium implants and grafted femora regained more than their innate mechanical stability: torsional strength exceeded twice their original strength. In conclusion, combining porous titanium implants with a physiologically concentrated fibrin gels loaded with BMP-2 improved bone regeneration in load-bearing segmental defects. This material combination now awaits its evaluation in larger animal models to show its suitability for grafting load-bearing defects in trauma and orthopaedic surgery.
机译：承重的节段性骨缺损的再生是创伤和整形外科手术中的主要挑战。理想的骨移植替代物是一种生物材料，可提供即时的机械稳定性，同时在短时间内刺激骨骼再生以完全弥补缺损。因此，设计并微调以允许完全承重的选择性激光熔融多孔钛填充了充满骨形态发生蛋白2（BMP-2）的生理浓缩纤维蛋白凝胶。这种生物材料用于移植大鼠的临界尺寸的股骨节段骨缺损。作为对照，将多孔钛植入物留空或用不含BMP-2的纤维蛋白凝胶填充。我们使用体内和体外µCT扫描，组织学和扭转测试评估了移植股骨的骨再生，骨质量和机械强度。这种生物材料在八周内完全再生并弥合了临界尺寸的骨缺损。十二周后，股骨在解剖学上重塑，并显示出开放的髓腔。更重要的是，在整个多孔钛植入物中形成了新的骨骼，并且股骨移植物获得了超过其固有的机械稳定性的更多信息：扭转强度超过了其原始强度的两倍。总之，将多孔钛植入物与负载BMP-2的生理浓缩纤维蛋白凝胶结合使用可改善承重节段性骨的骨再生。现在，这种材料组合正在等待在较大动物模型中进行评估，以显示其是否适合移植创伤和整形外科手术中的承重缺陷。

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