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首页> 外文期刊>European Cells & Materials >A biodegradable gentamicin-hydroxyapatite-coating for infection prophylaxis in cementless hip prostheses
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A biodegradable gentamicin-hydroxyapatite-coating for infection prophylaxis in cementless hip prostheses

机译：一种可生物降解的庆大霉素-羟基磷灰石涂层，用于预防非骨水泥髋关节假体的感染

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摘要

A degradable, poly (lactic-co-glycolic acid) (PLGA), gentamicin-loaded prophylactic coating for hydroxyapatite (HA)-coated cementless hip prostheses is developed with similar antibacterial efficacy as offered by gentamicin-loaded cements for fixing traditional, cemented prostheses in bone. We describe the development pathway, from in vitro investigation of antibiotic release and antibacterial properties of this PLGA-gentamicin-HA-coating in different in vitro models to an evaluation of its efficacy in preventing implant-related infection in rabbits. Bone in-growth in the absence and presence of the coating was investigated in a canine model. The PLGA-gentamicin-HA-coating showed high-burst release, with antibacterial efficacy in agar-assays completely disappearing after 4 days, minimising risk of inducing antibiotic resistance. Gentamicin-sensitive and gentamicin-resistant staphylococci were killed by the antibiotic-loaded coating, in a simulated prosthesis-related interfacial gap. PLGA-gentamicin-HA-coatings prevented growth of bioluminescent staphylococci around a miniature-stem mounted in bacterially contaminated agar, as observed using bio-optical imaging. PLGA-gentamicin-HA-coated pins inserted in bacterially contaminated medullary canals in rabbits caused a statistically significant reduction in infection rates compared to HA-coated pins without gentamicin. Bone ingrowth to PLGA-gentamicin-HA-coated pins, in condylar defects of Beagle dogs was not impaired by the presence of the degradable, gentamicin-loaded coating. In conclusion, the PLGA-gentamicin-HA-coating constitutes an effective strategy for infection prophylaxis in cementless prostheses.
机译：开发了一种可降解的聚乳酸乙醇酸庆大霉素负载预防性涂料，用于羟基磷灰石（HA）涂覆的非骨水泥髋关节假体，其抗菌功效与庆大霉素填充的水泥相似，可用于固定传统的骨水泥假体在骨头里。我们描述了从不同的体外模型中这种PLGA-庆大霉素-HA-涂层的抗生素释放和抗菌性能的体外研究到其预防兔植入相关感染的功效的评估的发展途径。在犬模型中研究在不存在和存在涂层的情况下骨的向内生长。 PLGA-庆大霉素-HA涂层显示出高爆裂释放，琼脂测定中的抗菌作用在4天后完全消失，从而最大程度地降低了诱导抗生素耐药性的风险。庆大霉素敏感性和庆大霉素耐药性葡萄球菌在模拟的假体相关界面间隙中被加载抗生素的涂层杀死。 PLGA-庆大霉素-HA涂层可以防止生物发光的葡萄球菌在安装于细菌污染的琼脂中的微型杆周围生长。与没有庆大霉素的HA涂层针相比，将PLGA-庆大霉素-HA涂层针插入兔子的细菌污染的髓管会导致感染率的降低。在Beagle犬的defects突缺损中，PLGA-庆大霉素-HA涂层的销钉的骨向内生长不会受到可降解的，装有庆大霉素的涂层的存在的影响。总之，PLGA-庆大霉素-HA涂层是预防非骨水泥假体感染的有效策略。

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