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首页> 外文期刊>European Journal of Histochemistry >Age-related changes of monoaminooxidases in rat cerebellar cortex
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Age-related changes of monoaminooxidases in rat cerebellar cortex

机译：大鼠小脑皮质中单氨基氧化酶的年龄相关变化

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摘要

Age-related changes of the monoaminoxidases, evaluated by enzymatic staining, quantitative analysis of images, biochemical assay and statistical analysis of data were studied in cerebellar cortex of young (3-month-old) and aged (26- month-old) male Sprague-Dawley rats. The enzymatic staining shows the presence of monoamino-oxidases within the molecular and granular layers as well as within the Purkinje neurons of the cerebellum of young and aged animals. In molecular layer, and in Purkinje neurons the levels of monoaminooxidases were strongly increased in old rats. The granular layer showed, on the contrary, an age-dependent loss of enzymatic staining. These morphological findings were confirmed by biochemical results. The possibility that age-related changes in monoaminooxidase levels may be due to impaired energy production mechanisms and/or represent the consequence of reduced energetic needs is discussed.
机译：通过酶染色，图像定量分析，生化分析和数据统计分析评估了单氨基二糖酶与年龄相关的变化，研究对象为年轻（3个月大）和年龄较大（26个月大）的雄性Sprague小脑皮质-Dawley大鼠。酶染色显示在幼小和成年动物的小脑的分子层和颗粒层以及浦肯野神经元中均存在单氨基氧化酶。在分子层和浦肯野神经元中，老年大鼠中的单氨基氧化酶水平大大增加。相反，颗粒层显示出随年龄增长的酶促染色损失。这些形态学发现被生化结果证实。讨论了与年龄有关的单氨基氧化酶水平变化可能是由于能量产生机制受损和/或代表了能量需求减少的结果的可能性。

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