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首页> 外文期刊>European Cells & Materials >Poly(trimethylene carbonate) and poly(D,L-lactic acid) modify human dendritic cell responses to staphylococci but do not affect Th1 and Th2 cell development
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Poly(trimethylene carbonate) and poly(D,L-lactic acid) modify human dendritic cell responses to staphylococci but do not affect Th1 and Th2 cell development

机译：聚碳酸三亚甲基酯和聚（D，L-乳酸）修饰人树突状细胞对葡萄球菌的反应，但不影响Th1和Th2细胞的发育

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Biomaterial-associated infections (BAIs) are frequent complications in the use of medical devices (biomaterials) correlated with considerable patient discomfort and high treatment costs. The presence of a biomaterial in the host causes derangement of local immune responses increasing susceptibility to infection. Dendritic cells (DCs) have an important role in directing the nature of immune responses by activating and controlling CD4+ T helper (Th) cell responses. To assess the immunomodulatory effect of the combined presence of biomaterials and Staphylococcus aureus (S. aureus) or Staphylococcus epidermidis (S. epidermidis), DC-mediated T cell proliferation and Th1/Th2 cell development were measured using an in vitro human cell system. Poly(trimethylene carbonate) (PTMC) and poly(D,L-lactic acid) (PDLLA) modified the production of the DC pro-inflammatory cytokines TNF-α, IL-6 and IL-23 in response to S. aureus and S. epidermidis. However, this modified cytokine production did not cause differences in Th1/Th2 cell polarisation, showing a Th1 cell predominance. In the absence of staphylococci, neither of the biomaterials induced DC-mediated T cell proliferation or Th1/Th2 cell polarisation. Moreover, either in the absence or presence of the biomaterials, S. aureus was a more potent inducer of DC cytokine secretion, T cell proliferation and Th1 cell development than S. epidermidis. In conclusion, although PTMC and PDLLA modulated DC cytokine responses to staphylococci, this did not alter the resulting Th cell development. This result suggested that, in this human cell model, Th1/Th2 cell responses were mainly determined by the species of bacteria and that PTMC or PDLLA did not detectably influence these responses.
机译：生物材料相关感染（BAI）是医疗器械（生物材料）使用中的常见并发症，与患者的极大不适和高昂的治疗费用相关。宿主中生物材料的存在会引起局部免疫反应紊乱，从而增加对感染的敏感性。树突状细胞（DC）在通过激活和控制CD4 + T辅助（Th）细胞反应来指导免疫反应的性质中起重要作用。为了评估生物材料与金黄色葡萄球菌（S. aureus）或表皮葡萄球菌（S. epidermidis）联合存在的免疫调节作用，使用体外人细胞系统测量了DC介导的T细胞增殖和Th1 / Th2细胞发育。聚碳酸三亚甲基酯（PTMC）和聚（D，L-乳酸）（PDLLA）响应于金黄色葡萄球菌和S链菌素修饰DC促炎细胞因子TNF-α，IL-6和IL-23的产生。表皮但是，这种修饰的细胞因子产生并未引起Th1 / Th2细胞极化的差异，显示出Th1细胞占优势。在没有葡萄球菌的情况下，两种生物材料都不会诱导DC介导的T细胞增殖或Th1 / Th2细胞极化。此外，无论是否存在生物材料，金黄色葡萄球菌都比表皮葡萄球菌更有效地诱导DC细胞因子分泌，T细胞增殖和Th1细胞发育。总之，尽管PTMC和PDLLA调节了DC细胞因子对葡萄球菌的反应，但这并未改变所得Th细胞的发育。该结果表明，在该人类细胞模型中，Th1 / Th2细胞反应主要取决于细菌的种类，而PTMC或PDLLA并没有可检测地影响这些反应。

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