• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European Clinical Respiratory Journal >NT-proBNP 95 ng/l can exclude pulmonary hypertension on echocardiography at diagnostic workup in patients with interstitial lung disease
【24h】

NT-proBNP 95 ng/l can exclude pulmonary hypertension on echocardiography at diagnostic workup in patients with interstitial lung disease

机译：NT-proBNP <95 ng / l可在间质性肺病患者的诊断检查中通过超声心动图排除肺动脉高压

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BackgroundPulmonary hypertension (PH) is a serious complication to interstitial lung disease (ILD) and has a poor prognosis. PH is often diagnosed by screening with echocardiography followed by right heart catheterisation. A previous study has shown that a value of NT-pro-brain natriuretic peptide (NT-proBNP) 95 ng/l could be used to rule out PH in patients with ILD.AimTo evaluate this rule-out test for PH in a new cohort of incident patients with ILD.MethodsAn established database with data from 148 consecutive patients referred from January 2012 to October 2014 was used to identify patients and obtain data from echocardiography, NT-proBNP, diagnosis and lung function. Signs of PH on echocardiography were defined as a tricuspid pressure gradient (TR) ≥40 mmHg, decreased right ventricular systolic function or dilatation. Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) of NT-proBNP 95 ng/l for signs of PH on echocardiography were calculated. The study was approved by the Danish Health Authority.ResultsIn 118 patients, data from both echocardiography and measurements of NT-proBNP were available. Eleven of these were screened positive for PH on echocardiography. Sensitivity, specificity, NPV and PPV of NT-proBNP 95 ng/l for PH were 100, 44, 16 and 100%, respectively. Furthermore, no patients with left heart failure as the cause of dyspnoea were missed using this cut-off value.ConclusionNT-proBNP 95 ng/l precludes a positive echocardiographic screen for PH in ILD patients at referral for diagnostic workup.
机译：背景肺动脉高压（PH）是间质性肺疾病（ILD）的严重并发症，预后较差。通常通过超声心动图筛查，然后进行右心导管检查来诊断PH。先前的一项研究表明，NT-proBNP（ 95 ng / l对PH的敏感性，特异性，阴性预测值（NPV）和阳性预测值（PPV）。结果该研究得到丹麦卫生当局的批准。结果有118例患者获得了超声心动图和NT-proBNP测量数据。其中11个在超声心动图上筛查出PH呈阳性。 <95 ng / l的NT-proBNP对PH的敏感性，特异性，NPV和PPV分别为100％，44％，16％和100％。此外，使用该临界值，不会遗漏任何因呼吸困难而引起的左心衰竭患者。结论NT-proBNP <95 ng / l排除了转诊诊断性ILD患者的超声心动图筛查阳性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号