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首页> 外文期刊>European Clinical Respiratory Journal >Bad news itself or just the messenger? The high mortality of Fusobacterium spp. infections is related to disseminated malignancy and other comorbidities
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Bad news itself or just the messenger? The high mortality of Fusobacterium spp. infections is related to disseminated malignancy and other comorbidities

机译：坏消息本身还是仅仅是使者？镰刀菌属的高死亡率。感染与弥漫性恶性肿瘤和其他合并症有关

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BackgroundFusobacterium species are pleomorphic, obligate anaerobic gram-negative bacilli. They are difficult to culture and grow slowly. If antibiotic treatment is initiated prior to blood cultures, the bacteria might evade detection. This is a comprehensive report on mortality in non-bacteraemia fusobacterial infection.MethodsData were collected retrospectively in adults having a positive culture with Fusobacterium spp. admitted during 2000–2012 at the medical department. Data on culture specimens, number of cultures, admission and culture dates, patient age, gender, clinical disease, Charlson's index of co-morbidity, CRP level and survival were obtained. For comparison, we traced 60 consecutive, similarly obtained cultures from 2009 to 2010 containing Staphylococcus aureus .ResultsWithin a 12-year period, we identified 28 patients with a positive culture of Fusobacterium spp. in a medical ward serving a population of 220,000. Only a minority (39%) had a positive blood culture, and 54% had focus in respiratory tract or pleura. Overall 6-month mortality was 32%, and unrelated to subspecies, treatment or anatomic location but significantly related to age 60 years, admission for severe, acute illness, and comorbidity, especially metastatic malignancy. Comparison between infection with Fusobacterium spp. and S. aureus showed that Fusobacterium spp. infections were predominantly community acquired, while S. aureus were both community and hospital acquired. Overall mortality for both bacterial infections increased significantly with age and current malignant disease. S. aureus– infected patients carried a significantly higher mortality.ConclusionOur data support that Fusobacterium spp. infection is a marker for significant, chronic disease rather than carrying a poor prognosis per se .
机译：背景融合细菌是多形的专性厌氧革兰氏阴性杆菌。它们难以培养并且生长缓慢。如果在血液培养之前开始抗生素治疗，细菌可能会逃避检测。这是关于非细菌性融合细菌感染死亡率的综合报告。方法回顾性收集成年融合杆菌属呈阳性的成年人的数据。 2000年至2012年期间在医学科住院。获得有关培养标本，培养次数，入院和培养日期，患者年龄，性别，临床疾病，查尔森共病指数，CRP水平和生存率的数据。为了进行比较，我们追踪了2009年至2010年连续60次相似获得的含有金黄色葡萄球菌的培养物。结果在12年的时间内，我们确定了28例阳性细菌为融合杆菌的患者。在为22万人口服务的医疗病房中。只有少数（39％）的血液培养呈阳性，而54％的病灶集中在呼吸道或胸膜。总体6个月死亡率为32％，与亚种，治疗或解剖位置无关，但与年龄> 60岁，重症，急性疾病和合并症（尤其是转移性恶性肿瘤）的入院显着相关。融合杆菌感染之间的比较。和 S。金黄色葡萄球菌显示融合杆菌。感染主要是社区获得性感染，而 S。社区和医院都获得了金黄色葡萄球菌。两种细菌感染的总体死亡率均随年龄和当前的恶性疾病而显着增加。 S。金黄色葡萄球菌感染的患者死亡率更高。结论我们的数据支持融合杆菌属。感染是严重的慢性疾病的标志，而不是预后较差的本身。

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