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首页> 外文期刊>European Journal of Medicinal Plants >Anti-Allergic Action of Aqueous Extract of Moringa oleifera Lam. Leaves in Mice
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Anti-Allergic Action of Aqueous Extract of Moringa oleifera Lam. Leaves in Mice

机译：辣木水提取物的抗过敏作用。老鼠离开

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Aims: The present investigation aimed to evaluate anti-allergic activity of an aqueous extract of Moringa oleifera Lam. leaves (AqMOL) in three type I allergy models in mice. Study Design: Anti-allergic assay of AqMOL was performed using three type I allergy models in mice. Place and Duration of Study: Department of Biochemistry, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, Nobeoka, Japan, from April 2014 to March 2015. Methodology: AqMOL (300 mg/kg) was orally administered to mice three times daily from two days before treatments in compound 48/80 (48/80) stimulation and passive cutaneous anaphylaxis (PCA) reaction models, and scratching frequencies and Evans blue levels in the ears, respectively, after treatments were measured. In an ovalbumin (OVA) sensitization model, AqMOL was continuously ingested ad libitum by mice from day 0 to day 45, and scratching frequencies of OVA-sensitized mice were measured after an intranasal OVA challenge. Histamine and total and OVA-specific IgE levels in the sera were also measured. Results: AqMOL significantly reduced scratching frequencies in the 48/80 stimulation and OVA sensitization models. In the PCA reaction model, AqMOL reduced Evans blue levels in the ears of mice after specific IgE injection, although not statistically significantly. In OVA-sensitized mice, AqMOL significantly reduced OVA-specific IgE levels in the serum, but histamine and total IgE levels were not significantly affected by AqMOL administration. Conclusion: AqMOL was suggested to alleviate allergic symptoms through suppression of mast cell activation and/or improving the Th1/Th2 balance to Th1 dominance in allergic mice. The elucidation of mode of anti-allergy action of AqMOL may provide new insights into the usage of AqMOL as a functional food for the alleviation of type 1 allergy.
机译：目的：本研究旨在评估辣木水提取物的抗过敏活性。在小鼠的三种I型变态反应模型中均处于叶片（AqMOL）状态。研究设计：在小鼠中使用三种I型过敏模型进行AqMOL的抗过敏试验。研究地点和持续时间：2014年4月至2015年3月，日本九州保健福利大学临床药学院研究生院生物化学系。方法：对小鼠口服AqMOL（300 mg / kg）三次从治疗前两天开始，每天在化合物48/80（48/80）刺激和被动皮肤过敏（PCA）反应模型中进行治疗，并测量治疗后耳朵的抓挠频率和伊文思蓝水平。在卵清蛋白（OVA）致敏模型中，从第0天到第45天，小鼠连续自由摄入AqMOL，并在鼻内OVA攻击后测量OVA致敏小鼠的抓挠频率。还测量了血清中的组胺以及总的和OVA特异性的IgE水平。结果：在48/80刺激和OVA致敏模型中，AqMOL显着降低了抓挠频率。在PCA反应模型中，AqMOL降低了特异性IgE注射后小鼠耳朵中伊文思蓝的水平，尽管在统计学上不显着。在OVA致敏的小鼠中，AqMOL显着降低了血清中OVA特异性IgE的水平，但组胺和总IgE的水平并未受到AqMOL给药的显着影响。结论：AqMOL被建议通过抑制肥大细胞激活和/或改善Th1 / Th2对Th1优势的平衡来减轻过敏症状。阐明AqMOL的抗过敏作用方式可能为将AqMOL用作缓解1型过敏的功能性食品提供新见解。

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