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首页> 外文期刊>European Journal of Histochemistry >Immunolocalisation of vasoactive intestinal peptide and substance P in the developing gut of Dicentrarchus labrax (L.)
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Immunolocalisation of vasoactive intestinal peptide and substance P in the developing gut of Dicentrarchus labrax (L.)

机译：香茅（Dicentrarchus labrax）（L.）的发育中肠道中血管活性肠肽和P物质的免疫定位

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摘要

This study was carried out on the sea bass (Dicentrarchus labrax) to follow, during development, the appearance and distribution of substance P (SP) and vasoactive intestinal peptide (VIP), which act on gut motility. The results suggest that SP and VIP play an important role as neuromodulators, influencing the motility of the digestive tract starting from the early stages of gut development, even prior to exotrophic feeding. In the peptidergic nervous system, the appearance of immunoreactivity to SP began at the rectum and followed a distal to proximal gradient, whereas for VIP, it began proximally and progressed along a proximal to distal gradient. The two peptides also appeared in gut epithelial cells. In some regions, all the cells were positive. From this distribution of positive cells, we conclude that these peptides may also have other roles, besides being neurotransmitters in the enteric nervous system and hormones of the gastro-enteropancreatic system. VIP and SP might have paracrine and/or autocrine activity in the physiological maturation of the gut epithelium, as it has already been hypothesised for other peptides.
机译：这项研究是在鲈鱼（Dicentrarchus labrax）上进行的，目的是在发育过程中跟踪影响肠道蠕动的P物质（SP）和血管活性肠肽（VIP）的出现和分布。结果表明，SP和VIP作为神经调节剂起着重要的作用，从肠道发育的早期开始，甚至在营养外摄食之前，都会影响消化道的运动。在肽能神经系统中，对SP的免疫反应性的出现始于直肠，并从远端到近端渐变，而VIP则从近端开始，并沿着近端至远端渐变进行。这两种肽也出现在肠道上皮细胞中。在某些区域，所有细胞均为阳性。从阳性细胞的这种分布，我们得出结论，这些肽除了在肠神经系统中的神经递质和胃肠胰系统的激素外，还可能具有其他作用。 VIP和SP在肠道上皮的生理成熟中可能具有旁分泌和/或自分泌活性，因为已经假设其他肽也是如此。

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