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首页> 外文期刊>European Journal of Medicinal Plants >Lead Acetate Induced Cerebral Tissue Damage; The Effect of Phoenix dactylifera Pits Extract
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Lead Acetate Induced Cerebral Tissue Damage; The Effect of Phoenix dactylifera Pits Extract

机译：醋酸铅引起的脑组织损伤;凤蝶坑提取物的作用

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This study investigates effect of Phoenix dactylifera pits extract (PdPE) on Lead acetate induced cerebral tissue damage. Wistar rats of average weight 150 g were divided into seven groups of six animals each. GRPI animals received distilled water only, GRPII received 60 mg/kg Lead acetate 5 times a week for 3 weeks then distilled water only for ten days (Negative control), GRPIII and GRPIV (treatment groups) received 60 mg/kg Lead acetate 5 times a week for 3 weeks then treated with 150 mg/kg PdPE and 300 mg/kg PdPE respectively for 10 days, Group V and Group VI (protective groups) received 150 mg/kg PdPE and 300 mg/kg PdPE respectively for 10 days then 60 mg/kg Lead acetate 5 times a week for 3weeks, while GRPVII animals received 60 mg/kg Lead acetate 5 times a week for 3 weeks then treated with 25 mg/kg Dimercaptosuccinic acid?(DMSA) alone 4 times a week then distilled water for 3 days. Lead acetate induced cerebral tissue damage was evident from depleted reduced-glutathione and lipid peroxidation as shown by elevated malondialdehyde and nitrite concentration. Histological examination of the cerebral tissue showed congestion of the meningeal vessels and cellular infiltration. Malondialdehyde and nitrite were significantly reduced by 300 mg/kg PdPE (P<0.03). 300 mg/kg PdPE protective and treatment groups and 25 mg/kg DMSA ameliorates antioxidant depletion and showed significant protective effect against cerebral tissue damage. Memory assessment showed that 300 mg/kg PdPE and 25 mg/kg DMSA treatment significantly alleviate memory impairment induced by Lead acetate. Results from the study indicate that PdPE has the ability to alleviate lead acetate induced cerebral tissue damage in rats. PdPE may exert its protective and therapeutic effect against lead-induced cerebral damage possibly through its antioxidant mechanisms and due to the presence of membrane protecting unsaturated fatty acids.
机译：这项研究调查了凤凰果蝇坑提取物（PdPE）对醋酸铅诱导的脑组织损伤的影响。将平均重量为150 g的Wistar大鼠分成7组，每组6只动物。 GRPI动物仅接受蒸馏水，GRPII每周接受5次60毫克/千克醋酸铅，持续3周，然后仅接受十天的蒸馏水（阴性对照），GRPIII和GRPIV（治疗组）接受60毫克/千克醋酸铅5次每周3周，然后分别用150 mg / kg PdPE和300 mg / kg PdPE处理10天，第V组和第VI组（保护组）分别接受150 mg / kg PdPE和300 mg / kg PdPE 10天，然后60 mg / kg醋酸铅3周，每周5次，而GRPVII动物每周5次，每周5次接受60 mg / kg醋酸铅，然后连续25次每周蒸馏4次，每次25 mg / kg Dimercaptosuccinic acid？水3天。减少的谷胱甘肽和脂质过氧化作用明显证明乙酸铅诱导的脑组织损伤，如丙二醛和亚硝酸盐浓度升高。脑组织的组织学检查显示脑膜血管充血和细胞浸润。丙二醛和亚硝酸盐显着降低了300 mg / kg PdPE（P <0.03）。 300 mg / kg PdPE保护和治疗组以及25 mg / kg DMSA改善了抗氧化剂的消耗，并显示出对脑组织损伤的显着保护作用。记忆力评估显示300 mg / kg的PdPE和25 mg / kg的DMSA处理可显着缓解醋酸铅引起的记忆力减退。研究结果表明，PdPE具有减轻醋酸铅诱导的大鼠脑组织损伤的能力。 PdPE可能通过其抗氧化剂机制以及由于存在膜保护性不饱和脂肪酸而发挥了针对铅引起的脑损伤的保护和治疗作用。

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