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首页> 外文期刊>European Journal of Medicinal Plants >The Effect of Hydroalcoholic Extract of Ferulago angulata on Liver Function Parameters and Antioxidant Status in Alloxan-Induced Diabetic Rats
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The Effect of Hydroalcoholic Extract of Ferulago angulata on Liver Function Parameters and Antioxidant Status in Alloxan-Induced Diabetic Rats

机译：阿魏提取物对四氧嘧啶致糖尿病大鼠肝功能参数和抗氧化状态的影响。

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Aim: The aim of this study was to evaluate the hepatoprotective and antioxidant activities of Ferulago angulata Extract (FAE) in experimental diabetic rats. Materials and Methods: 54 adult male Wistar rats divided into 6 groups (n=9). Diabetes was induced in all animals except those in group 1 by the daily intraperitoneal injection of 120 mg/kg alloxan monohydrate for 3 consecutive days. Experimental diabetic rats in groups 3-5 were orally administered with FAE (200,400, and 800 mg/kg/day, respectively). Group 6 was treated with 150 mg/kg of metformin. At the end of week 4, the rats were anesthetized and then sacrificed by cardiac puncture. Then, the levels of liver markers, malondialdehyde (MDA), and antioxidant enzymes capacity were evaluated in each group. Results: Treatment with FAE resulted in a significant reduction in aspartate transaminase (AST) and alanine transaminase (ALT) activities as well as in the serum and liver tissue contents of MDA in comparison to the diabetic control group (P Conclusions: These findings suggest that FAE can reduce the complications of diabetes, prevent oxidative stress, and improve antioxidant status in diabetic rats.
机译：目的：本研究的目的是评估实验性糖尿病大鼠中安氏Ferulago angulata提取物（FAE）的保肝和抗氧化活性。材料与方法：54只成年雄性Wistar大鼠分为6组（n = 9）。除第1组动物外，其他所有动物均通过连续3天每天腹膜内注射120 mg / kg一水四氧嘧啶水合物诱导糖尿病。 3-5组的实验性糖尿病大鼠口服FAE（分别为200,400和800 mg / kg /天）。第6组用150 mg / kg的二甲双胍治疗。在第4周结束时，将大鼠麻醉，然后通过心脏穿刺处死。然后，评估各组中肝脏标志物，丙二醛（MDA）和抗氧化酶的水平。结果：与糖尿病对照组相比，FAE治疗导致天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）活性以及MDA的血清和肝脏组织含量显着降低（P结论：这些发现表明， FAE可以减少糖尿病并发症，预防氧化应激并改善糖尿病大鼠的抗氧化状态。

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