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首页> 外文期刊>European Journal of Medicinal Plants >Antitrypanosomal Activity of Allium porrum Ethyl Acetate Bulb Extract in Trypanosoma brucei brucei Experimentally Infected Wister Albino Rats
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Antitrypanosomal Activity of Allium porrum Ethyl Acetate Bulb Extract in Trypanosoma brucei brucei Experimentally Infected Wister Albino Rats

机译：布鲁氏醋酸乙酯鳞茎提取物对布鲁氏锥虫经实验感染白化病大鼠的抗胰蛋白酶活性

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Aims: The present study investigated the antitrypanosomal activity of crude ethyl acetate bulb extracts of A. porrum plant against T. b. brucei. Methodology: Twenty five male albino rats were divided into five groups and infected with x106/ml of T. b. brucei. Group 1 was infected and untreated while groups 2-4 were infected and treated with single intraperitoneal injection 50, 75 and 100 mg/kg of ethyl acetate extract of A. porrum while a single dose 3.5 mg/kg diaminazene aceturate was administered to group 5 when parasitaemia was established at x106 day 5 post infection. Results: Clinical manifestations of trypanosomoses such as increased rectal temperature, weakness and dullness were observed in experimental rats in all the groups. There was decrease packed cell volume (PCV) and red blood cell count (RBC) in group 1-4 which was not significant (p>0.05) while group 5 had a significant increase (p0.05) in RBC post treatment. There were feeble changes in the pre-treatment and post-treatment parasitemia level in the groups treated with ethyl acetate extract of A. porrum while there was significant clearance in parasitemia in the control group. Conclusion: Interperitoneal injection of ethyl acetate extracts of A. porrum at the dose and concentration used in this study, has trypanosomal reduction activity in wister rats.
机译：目的：本研究研究了A. porrum植物的乙酸乙酯粗提物对锥虫的抗锥虫活性。布鲁西。方法：将25只雄性白化病大鼠分为5组，并用x10 6 / ml的T. b。感染。布鲁西。第1组感染并未经治疗，而第2-4组感染并通过腹膜内注射50、75和100 mg / kg曲霉的乙酸乙酯提取物进行治疗，而第5组则单次注射3.5 mg / kg乙二氮杂乙酸酯当在感染后第5天x106建立了寄生虫血症。结果：在所有组的实验大鼠中均观察到锥虫病的临床表现，例如直肠温度升高，虚弱和迟钝。 1-4组中的填充细胞体积（PCV）和红细胞计数（RBC）降低，这不显着（p> 0.05），而5组在治疗后RBC显着增加（p0.05）。用A.porrum的乙酸乙酯提取物治疗的组中，治疗前后的寄生虫病水平变化很小，而对照组中的寄生虫病清除率明显升高。结论：腹膜内注射本实验所用剂量和浓度的鸡骨曲霉乙酸乙酯提取物具有降低锥虫对衰老大鼠的活性。

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