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首页> 外文期刊>European Journal of Histochemistry >Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy
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Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy

机译：治疗后溃疡性结肠炎中Hsp10，Hsp70和Hsp90免疫组化水平的变化

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Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) characterized by damage of large bowel mucosa and frequent extra-intestinal autoimmune comorbidities. The role played in IBD pathogenesis by molecular chaperones known to interact with components of the immune system involved in inflammation is unclear. We previously demonstrated that mucosal Hsp60 decreases in UC patients treated with conventional therapies (mesalazine, probiotics), suggesting that this chaperonin could be a reliable biomarker useful for monitoring response to treatment, and that it might play a role in pathogenesis. In the present work we investigated three other heat shock protein/molecular chaperones: Hsp10, Hsp70, and Hsp90. We found that the levels of these proteins are increased in UC patients at the time of diagnosis and decrease after therapy, supporting the notion that these proteins deserve attention in the study of the mechanisms that promote the development and maintenance of IBD, and as biomarkers of this disease (e.g., to monitor response to treatment at the histological level).
机译：溃疡性结肠炎（UC）是一种炎症性肠病（IBD），其特征是大肠粘膜受损和频繁的肠外自身免疫性合并症。尚不清楚分子伴侣在IBD发病机理中所起的作用，这些分子伴侣已知与参与炎症的免疫系统的成分相互作用。我们先前证明，在使用传统疗法（美沙拉嗪，益生菌）治疗的UC患者中，粘膜Hsp60降低，这表明这种伴侣蛋白可能是可靠的生物标志物，可用于监测对治疗的反应，并且可能在发病机理中起作用。在目前的工作中，我们研究了其他三种热休克蛋白/分子伴侣：Hsp10，Hsp70和Hsp90。我们发现，在UC患者中，这些蛋白的水平在诊断时会升高，而在治疗后会降低，这支持了这些蛋白在促进IBD发生和维持的机制研究中值得关注的观点，并被认为是IBD的生物标志物。这种疾病（例如，在组织学水平上监测对治疗的反应）。

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