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首页> 外文期刊>European Journal of General Medicine >Red Blood Cell Distribution Width (RDW) and its Association with Coronary Atherosclerotic Burden in Patients with Stable Angina Pectoris
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Red Blood Cell Distribution Width (RDW) and its Association with Coronary Atherosclerotic Burden in Patients with Stable Angina Pectoris

机译：稳定型心绞痛患者红细胞分布宽度（RDW）及其与冠状动脉粥样硬化负担的关系

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Although there are several studies regarding the association between RDW and the vascular events, information is scant about possible role of RDW in cardiovascular system. We aimed to investigate whether RDW is related with the severity and extent of angiographically assessed coronary artery disease (CAD). Two hundred ninety and six stable eligible patients who had undergone coronary angiography with a suspicion of CAD were enrolled consecutively. Two hundred and nine (71%) of 296 patients had CAD (men 70%, mean age±SD: 61±11yrs) and 87 patients (29%) had normal coronary arteries (NCA) without any atherosclerotic lesion (men 48%, 52±11yrs). Red blood cell distribution width values were significantly different among the subgroups determined for the severity and extent of CAD. When 14.8% was accepted as the cut-off value for RDW, the sensitivity and the specificity for the detection of CAD was 68% and 52%. When we performed multiple logistic regression analysis to determine the independent predictors of CAD, we found a positive independent relationship between age, gender, family history of CAD and RDW and CAD. Our results show that RDW has a significant relationship with CAD independent of nonspecific inflammation and circulating inflammatory cells. Although we cannot conclude the underlying pathologic process of RDW, we believe that these findings may pave the way for further studies searching the role of RDW in atherosclerosis.
机译：尽管有几项有关RDW与血管事件之间关系的研究，但有关RDW在心血管系统中可能作用的信息很少。我们旨在调查RDW是否与血管造影评估的冠状动脉疾病（CAD）的严重程度和程度有关。连续纳入了296例因冠心病怀疑接受冠脉造影的稳定合格患者。 296例患者中有209例（71％）患有CAD（男性70％，平均年龄：SD±61yrs），而87例（29％）冠状动脉（NCA）正常但无动脉粥样硬化病变（男性48％， 52±11岁）。在确定CAD的严重程度和程度的亚组之间，红细胞分布宽度值显着不同。当以14.8％作为RDW的临界值时，检测CAD的灵敏度和特异性分别为68％和52％。当我们进行多元逻辑回归分析以确定CAD的独立预测因子时，我们发现CAD，RDW和CAD的年龄，性别，家族史之间存在正独立的关系。我们的结果表明，RDW与CAD有显着关系，而与非特异性炎症和循环性炎症细胞无关。尽管我们无法推断出RDW的潜在病理过程，但我们认为这些发现可能为进一步研究RDW在动脉粥样硬化中的作用铺平了道路。

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