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首页> 外文期刊>European Journal of General Medicine >An Unusual Presentation of Peutz-Jeghers Syndrome: A Case of Recurrent Jejunal Intussusception
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An Unusual Presentation of Peutz-Jeghers Syndrome: A Case of Recurrent Jejunal Intussusception

机译：Peutz-Jeghers综合征的异常表现：空肠肠套叠复发病例

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摘要

Epidemiologic studies show that sleep apnea increases risks for cardiovascular disease independently of individuals’ demographic characteristics or risk markers i.e., smoking, alcohol, obesity, diabetes, dyslipidemia, atrial fibrillation, and hypertension. Individuals with severe sleep apnea are at increased risk for pulmonary arterial hypertension. The underlying mechanisms explaining associations between obstructive sleep apnea and pulmonary arterial hypertension are not entirely delineated. Several intermediary mechanisms might be involved including sustained sympathetic activation, intrathoracic pressure changes, and oxidative stress. Other abnormalities such as disorders in coagulation factors, endothelial damage, platelet activation, and increased inflammatory mediators might also play a role in the pathogenesis of pulmonary hypertension and cardiovascular disease. Linkage between obstructive sleep apnea and pulmonary arterial hypertension is corroborated by evidence that treatment of sleep apnea with continuous positive airway pressure reduces systolic blood pressure, improves left ventricular systolic function, and diminishes platelet activation. Several systematic studies are necessary to explicate complex associations between sleep apnea and pulmonary hypertension.
机译：流行病学研究表明，睡眠呼吸暂停会增加心血管疾病的风险，而与个人的人口统计学特征或风险指标（例如，吸烟，酗酒，肥胖，糖尿病，血脂异常，心房颤动和高血压）无关。患有严重睡眠呼吸暂停的个体患肺动脉高压的风险增加。尚未完全阐明解释阻塞性睡眠呼吸暂停与肺动脉高压之间的关联的潜在机制。可能涉及多种中介机制，包括持续的交感神经激活，胸腔内压力变化和氧化应激。其他异常，例如凝血因子异常，内皮损伤，血小板活化和炎性介质增加，也可能在肺动脉高压和心血管疾病的发病机理中起作用。有证据表明，持续呼吸道正压治疗睡眠呼吸暂停可降低收缩压，改善左心室收缩功能并减少血小板活化，这证实了阻塞性睡眠呼吸暂停与肺动脉高压之间的联系。为了阐明睡眠呼吸暂停和肺动脉高压之间的复杂联系，必须进行一些系统的研究。

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