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The trochanteric fat pad

机译:股骨转子脂肪垫

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摘要

Technological developments based on the use of autologous white adipose tissue (WAT) attracted attention to minor fat depots as possible sources of adipose tissue. In plastic surgery, the trochanteric fatty pad is one of the most used WAT depots for its location and organoleptic characteristics that make it particularly suitable for reconstructive procedures. Despite its wide use in clinic, the structure of this depot has never been studied in detail and it is not known if structural differences exist among trochanteric fat and other subcutaneous WAT depots. The present study was performed on trochanteric fat pad with the aim to clarify the morphology of its adipocytes, stroma and microcirculation, with particular reference to the stem niches. Histological and ultrastructural studies showed that the main peculiar feature of the trochanteric fat concerns its stromal component, which appears less dense than in the other subcutaneous WATs studied. The intra-parenchymal collagen stroma is poor and the extracellular compartment shows large spaces, filled with electron-light material, in which isolated collagen bundles are present. The adipocytes are wrapped in weak and easily detachable collagen baskets. These connective sheaths are very thin compared to the sheaths in other subcutaneous WAT depots. The capillaries are covered by large, long and thin elements surrounded by an external lamina; these perivascular cells are poor in organelles and mainly contain poly-ribosomes. In conclusion, when compared to other WAT deposits, the trochanteric fatty pad shows structural peculiarities in its stroma and microcirculation suggesting a high regenerative potential. Resistance, dissociability, microvascular weft and high regenerative potential make the trochanteric fatty pad a privileged source for harvesting in autologous WAT-based regenerative procedures.
机译:基于自体白色脂肪组织(WAT)的技术发展引起了人们对作为脂肪组织可能来源的少量脂肪库的关注。在整形外科手术中,股骨转子脂肪垫因其位置和感官特性而成为最常用的WAT仓库之一,这使其特别适合于重建手术。尽管它在临床上得到了广泛的应用,但从未详细研究过该仓库的结构,并且尚不清楚转子肥大和其他皮下WAT仓库之间是否存在结构差异。本研究是在转子粗隆脂肪垫上进行的,旨在阐明其脂肪细胞,间质和微循环的形态,特别是针对干stem。组织学和超微结构研究表明,转子粗脂肪的主要特征与它的基质成分有关,基质成分比其他皮下WAT的密度要小。实质内胶原基质较差,胞外区显示较大的空间,充满电子光物质,其中存在孤立的胶原束。脂肪细胞包裹在脆弱且易于拆卸的胶原蛋白篮中。与其他皮下WAT仓库的护套相比,这些连接护套非常薄。毛细血管被大,长,细的元件所覆盖,并被外部叶片包围。这些血管周细胞的细胞器较弱,主要含有多核糖体。总之,与其他WAT沉积物相比,转子肥大性脂肪垫在基质和微循环方面显示出结构上的特殊性,这表明其再生潜力很高。抵抗力,可分离性,微血管纬线和较高的再生潜力使转子粗脂肪垫成为自体基于WAT的再生程序中收获的优先来源。

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