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首页> 外文期刊>European journal of endocrinology >Effects of 3-year GH replacement therapy on bone mineral density in younger and elderly adults with adult-onset GH deficiency
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Effects of 3-year GH replacement therapy on bone mineral density in younger and elderly adults with adult-onset GH deficiency

机译：3年GH替代疗法对成年GH缺乏的年轻和老年人的骨矿物质密度的影响

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ObjectiveLittle is known of the effects of long-term GH replacement on bone mineral content (BMC) and bone mineral density (BMD) in elderly GH-deficient (GHD) adults.Design/patients/methodsIn this prospective, single-center, open-label study, the effects of 3-year GH replacement were determined in 45 GHD patients >65 years and in 45 younger control GHD patients with a mean age of 39.5 (s.e.m. 1.1) years. All patients had adult-onset disease and both groups were comparable in terms of number of anterior pituitary hormonal deficiencies, gender, body mass index, and waist:hip ratio.ResultsThe mean maintenance dose of GH was 0.24 (0.02) mg/day in the elderly patients and 0.33 (0.02) mg/day in the younger GHD patients ( P <0.01). The 3 years of GH replacement induced a marginal effect on total body BMC and BMD, whereas femur neck and lumbar (L2–L4) spine BMC and BMD increased in both the elderly and the younger patients. The treatment response in femur neck BMC was less marked in the elderly patients ( P <0.05 vs younger group). However, this difference disappeared after correction for the lower dose of GH in the elderly patients using an analysis of covariance. There were no between-group differences in responsiveness in BMC or BMD at other skeletal locations.ConclusionsThis study shows that GH replacement increases lumbar (L2–L4) spine and femur neck BMD and BMC in younger as well as elderly GHD patients. This supports the notion that long-term GH replacement is also useful in elderly GHD patients.
机译：目的对于长期缺乏GH的老年人对GH缺乏的老年人（GHD）成年人的骨矿物质含量（BMC）和骨矿物质密度（BMD）的影响知之甚少。设计/患者/方法在这种前瞻性，单中心，开放性研究中标签研究中，确定了45名65岁以上的GHD患者和3名平均年龄为39.5（sem 1.1）岁的年轻对照GHD患者3年GH替代治疗的效果。所有患者均患有成人疾病，并且在垂体前叶激素缺乏症的数量，性别，体重指数和腰围：臀部比率方面，两组均具有可比性。结果GH的平均维持剂量为0.24（0.02）mg / day。老年患者，年轻的GHD患者为0.33（0.02）mg /天（P <0.01）。 GH置换3年对全身BMC和BMD的影响很小，而老年和年轻患者的股骨颈和腰（L2-L4）脊柱BMC和BMD均增加。老年患者股骨颈BMC的治疗反应较不明显（与年轻组相比，P <0.05）。但是，使用协方差分析校正老年患者较低的GH剂量后，这种差异消失了。结论在其他骨骼部位，BMC或BMD的反应性无组间差异。结论本研究表明，GH替代可增加年轻和老年GHD患者的腰椎（L2-L4）脊柱和股骨颈BMD和BMC。这支持长期GH替代对老年GHD患者也有用的观点。

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