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Oxygen therapy for interstitial lung disease: a systematic review

机译：间质性肺疾病的氧疗：系统评价

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This review aims to establish the impact of oxygen therapy on dyspnoea; health-related quality of life (HRQoL); exercise capacity and mortality in interstitial lung disease (ILD).We included studies that compared oxygen therapy to no oxygen therapy in adults with ILD. No limitations were placed on study design or intervention type. Two reviewers independently evaluated studies for inclusion; assessed risk of bias and extracted data. The primary outcome was dyspnoea.Eight studies evaluated the acute effects of oxygen (n=1509). There was no effect of oxygen therapy on modified Borg dyspnoea score at end exercise (mean difference (MD) xe2x88x920.06xe2x80x85units; 95% CI xe2x88x920.24xe2x80x930.13; two studies; n=27). However; effects on exercise outcomes consistently favoured oxygen therapy. One study showed reduction in dyspnoea at rest with oxygen in patients who were acutely unwell (MD visual analogue scale 30xe2x80x85mm versus 48xe2x80x85mm; p<0.05; n=10). Four studies of long-term oxygen therapy (n=2670) had high risk of bias and no inferences could be drawn.This systematic review showed no effects of oxygen therapy on dyspnoea during exercise in ILD; although exercise capacity was increased. Future trials should evaluate whether acute improvements in exercise capacity with oxygen can be translated into improved physical activity and HRQoL.
机译：这篇综述旨在确定氧气疗法对呼吸困难的影响。与健康有关的生活质量（HRQoL）;间质性肺疾病（ILD）的运动能力和死亡率。我们纳入的研究比较了成人ILD患者中氧疗与不氧疗的比较。对研究设计或干预类型没有限制。两名审稿人独立评估了研究的纳入性;评估偏见风险并提取数据。主要结果是呼吸困难。八项研究评估了氧气的急性作用（n = 1509）。氧疗对运动结束后的博格呼吸困难评分没有影响（平均差（MD）xe2x88x920.06xe2x80x85单位; 95％CI xe2x88x920.24xe2x80x930.13;两项研究; n = 27）。然而;对运动结局的影响一直有利于氧疗。一项研究表明，急性不适的患者在休息时服用氧气可减少呼吸困难（MD视觉模拟标尺30xe2x80x85mm与48xe2x80x85mm; p <0.05; n = 10）。长期氧疗的四项研究（n = 2670）具有较高的偏倚风险，无法得出任何推论。该系统评价表明，氧疗对ILD运动期间的呼吸困难无影响;虽然运动量增加了。未来的试验应评估是否可以将有氧运动能力的急性改善转化为体育锻炼和HRQoL的改善。

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