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首页> 外文期刊>European respiratory review >Epithelial cell migration as a potential therapeutic target in early lung cancer
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Epithelial cell migration as a potential therapeutic target in early lung cancer

机译：上皮细胞迁移是早期肺癌的潜在治疗靶标

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摘要

Lung cancer is the most lethal cancer type worldwide; with the majority of patients presenting with advanced stage disease. Targeting early stage disease pathogenesis would allow dramatic improvements in lung cancer patient survival. Recently; cell migration has been shown to be an integral process in early lung cancer ontogeny; with preinvasive lung cancer cells shown to migrate across normal epithelium prior to developing into invasive disease. TP53 mutations are the most abundant mutations in human nonsmall cell lung cancers and have been shown to increase cell migration via regulation of Rho-GTPase protein activity. In this review; we explore the possibility of targeting TP53-mediated Rho-GTPase activity in early lung cancer and the opportunities for translating this preclinical research into effective therapies for early stage lung cancer patients.
机译：肺癌是全球最致命的癌症类型。大多数患者患有晚期疾病。靶向早期疾病的发病机制将使肺癌患者的存活率显着提高。最近;细胞迁移已被证明是早期肺癌发生中不可或缺的过程。浸润前的肺癌细胞在发展为浸润性疾病之前会迁移穿过正常上皮。 TP53突变是人类非小细胞肺癌中最丰富的突变，已显示可通过调节Rho-GTPase蛋白活性来增加细胞迁移。在这篇评论中;我们探讨了靶向TP53介导的Rho-GTPase活性在早期肺癌中的可能性，以及将该临床前研究转化为早期肺癌患者有效疗法的机会。

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