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首页> 外文期刊>European Journal of Histochemistry >Rise, fall and resurrection of chromosome territories: a historical perspective. Part I. The rise of chromosome territories
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Rise, fall and resurrection of chromosome territories: a historical perspective. Part I. The rise of chromosome territories

机译:染色体领土的兴衰,复活:历史的观点。第一部分染色体区域的兴起

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It is now generally accepted that chromosomes in the cell nucleus are organized in distinct domains, first called chromosome territories in 1909 by the great cytologist Theodor Boveri. Yet, even today chromosomes have remained enigmatic individuals, whose structures, arrangements and functions in cycling and post-mitotic cells still need to be explored in full detail. Whereas numerous recent reviews describe present evidence for a dynamic architecture of chromosome territories and discuss the potential significance within the functional compartmentalization of the nucleus, a comprehensive historical account of this important concept of nuclear organization was lacking so far. Here, we describe the early rise of chromosome territories within the context of the discovery of chromosomes and their fundamental role in heredity, covering a period from the 1870th to the early 20th century (part I, this volume). In part II (next volume) we review the abandonment of the chromosome territory concept during the 1950th to 1980th and the compelling evidence, which led to its resurrection during the 1970th to 1980th.
机译:现在人们普遍认为,细胞核中的染色体组织在不同的域中,伟大的细胞学家Theodor Boveri于1909年首次将其称为染色体领地。然而,即使到了今天,染色体仍是神秘的个体,其循环,有丝分裂后细胞中的结构,排列和功能仍需要详细研究。尽管最近的许多评论都描述了染色体领土动态结构的现有证据,并讨论了核功能分区中的潜在意义,但迄今为止,对这种重要的核组织概念尚缺乏全面的历史记载。在这里,我们描述了在发现染色体的背景下染色体领地的早期兴起及其在遗传中的基本作用,涵盖了从1870年到20世纪初的时期(第一部分,本册)。在第二部分(下一部分)中,我们回顾了1950到1980年代对染色体区域概念的放弃以及令人信服的证据,这些证据导致其在1970到1980年代复活。

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