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首页> 外文期刊>European review for medical and pharmacological sciences. >Expression of MMP-13 is associated with invasion and metastasis of papillary thyroid carcinoma
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Expression of MMP-13 is associated with invasion and metastasis of papillary thyroid carcinoma

机译：MMP-13的表达与甲状腺乳头状癌的侵袭转移有关

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BACKGROUND: Collagenase-3 (MMP-13), a matrix metalloproteinase, is a recently identified member of the matrix metalloproteinases (MMPs) with broad substrate specificity, and a potential role in tumor metastasis and invasion has been proposed. Collagenase-3 expression has been reported in many carcinomas. However, the presence and possible implication of MMP-13 in the progression of papillary thyroid carcinomas are unknown. MATERIALS AND METHODS: In the present study, we examined MMP-13 gene expression in 208 papillary thyroid carcinomas who underwent surgery without preoperative treatment and 100 matched samples of adjacent normal thyroid tissue (Paraffin-embedded tissue samples) by immunohistochemistry analysis. In vitro and in vivo studies were done in order to investigate the effect of MMP-13 overexpression or silencing on cancer cells invasion and metastasis. RESULTS: We found MMP-13 expression was significantly increased in the tumours from local regional lymph node metastases patients. The MMP-13 was stained more intensely in invading fronts than in central portions of local regional lymph node. No MMP-13 staining was observed in matched samples of adjacent normal thyroid tissue. MMP-13 expression was significantly related with TNM and recurrent disease, no relation was found with age extent of tumour and size of tumour. Studies with cell and mice models indicated that overexpression of MMP-13 increased cell migration and promoted metastasis, and MMP-13 silencing decreased cell migration. CONCLUSIONS: The data suggest that MMP-13 is associated with thyroid tumour invasion and metastasis and it may be a potential target for therapeutic intervention.
机译：背景：胶原酶3（MMP-13）是一种基质金属蛋白酶，是基质金属蛋白酶（MMPs）中最近被鉴定的成员，具有广泛的底物特异性，并且已经提出了在肿瘤转移和侵袭中的潜在作用。已经报道了许多癌症中胶原酶3的表达。然而，在甲状腺乳头状癌的进展中，MMP-13的存在及其可能的意义尚不清楚。材料与方法：在本研究中，我们通过免疫组织化学分析检查了208例未经术前治疗的甲状腺乳头状癌的MMP-13基因表达以及100份匹配的正常甲状腺组织样本（石蜡包埋的组织样本）。为了研究MMP-13过表达或沉默对癌细胞侵袭和转移的影响，进行了体外和体内研究。结果：我们发现局部区域淋巴结转移患者的肿瘤中MMP-13表达显着增加。与局部区域淋巴结的中央部分相比，MMP-13的侵入前线染色更深。在相邻的正常甲状腺组织的匹配样品中未观察到MMP-13染色。 MMP-13的表达与TNM和复发性疾病密切相关，与肿瘤的年龄和肿瘤的大小无关。对细胞和小鼠模型的研究表明，MMP-13的过表达增加了细胞迁移并促进了转移，而MMP-13沉默则降低了细胞迁移。结论：数据提示MMP-13与甲状腺肿瘤的侵袭和转移有关，可能是治疗干预的潜在靶标。

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