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首页> 外文期刊>European review for medical and pharmacological sciences. >Study on the relationship between the expression of IGF-1 in umbilical cord blood and abnormal glucose metabolism during pregnancy
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Study on the relationship between the expression of IGF-1 in umbilical cord blood and abnormal glucose metabolism during pregnancy

机译：妊娠期脐血IGF-1表达与糖代谢异常的关系研究

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OBJECTIVE: To explore the relationship between the expression of insulin-like growth factor-1 (IGF-1) in neonatal umbilical cord blood and abnormal glucose metabolism during pregnancy. PATIENTS AND METHODS: We have selected 63 cases of delivery randomly, term birth and maternal from January 2015 to January 2016 in our hospital, gestational diabetes mellitus for Group A, abnormal gestational glucose tolerance for Group B and normal for Group C with 21 cases in each group. The venous blood samples were collected from all the pregnant females 2 weeks before delivery, and the levels of HbA1c in serum were detected by Elisa method. During the delivery, the umbilical cord blood was collected and the levels of IGF-1 were measured by double site immune enzyme analysis. The neonatal weight was recorded and the correlation analysis was made in respect of the measurement results. RESULTS: The level of HbA1c in Group A was significantly higher than that in Group C (p < 0.05); IGF-1 level and neonatal weight of Group B were significantly higher than that of Group C (p < 0.05), IGF-1 has a significant correlation with neonatal weight in Group C, and HbA1c and IGF-1 were positively correlated (p < 0.05); IGF-1 was positively correlated with neonatal weight in Group A and Group B (p < 0.05). There was a significant positive correlation between the IGF-1 level of neonatal umbilical cord blood and the neonatal weight (p < 0.05). Also, the level of HbA1c was positively correlated with the level of IGF-1 in neonatal umbilical cord blood at the end of pregnancy (p < 0.05). CONCLUSIONS: The expression level of IGF-1 in the final stage of pregnant females can be detected to predict the expression level of IGF-1 in newborn infants and then the growth status of the fetus can be obtained.
机译：目的：探讨新生儿脐带血中胰岛素样生长因子-1（IGF-1）的表达与妊娠期糖代谢异常的关系。患者与方法：我们从我院随机抽取了2015年1月至2016年1月的63例分娩，足月分娩和孕产妇，A组妊娠糖尿病，B组妊娠糖耐量异常和C组正常的21例。每组。分娩前2周从所有孕妇体内抽取静脉血，并通过Elisa法检测血清中的HbA1c水平。在分娩过程中，收集了脐带血，并通过双位点免疫酶分析法测量了IGF-1的水平。记录新生儿体重，并对测量结果进行相关分析。结果：A组HbA1c水平明显高于C组（p <0.05）; B组的IGF-1水平和新生儿体重显着高于C组（p <0.05），IGF-1与C组新生儿体重显着相关，HbA1c和IGF-1正相关（p <0.05）。 0.05）; A组和B组的IGF-1与新生儿体重呈正相关（p <0.05）。新生儿脐带血的IGF-1水平与新生儿体重之间存在显着正相关（p <0.05）。另外，妊娠结束时新生儿脐带血中HbA1c水平与IGF-1水平呈正相关（p <0.05）。结论：可以检测出妊娠末期IGF-1的表达水平，以预测IGF-1在新生儿中的表达水平，从而可以得出胎儿的生长状况。

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