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首页> 外文期刊>European review for medical and pharmacological sciences. >Physiological Intra-Cytoplasmic Sperm Injection (PICSI) outcomes after oral pretreatment and semen incubation with myo-inositol in oligoasthenoteratozoospermic men: results from a prospective, randomized controlled trial
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Physiological Intra-Cytoplasmic Sperm Injection (PICSI) outcomes after oral pretreatment and semen incubation with myo-inositol in oligoasthenoteratozoospermic men: results from a prospective, randomized controlled trial

机译：口服预处理和少肌无精症男性精子与肌醇一起精液孵育后的生理性细胞质内精子注射（PICSI）结果：一项前瞻性，随机对照试验的结果

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OBJECTIVE: The aim of the current study was to evaluate the effect of an oral pretreatment with a mix of myo-inositol (Myo-Ins), folic acid, vitamin E, L-carnitine, L-arginine and selenium (Folandrol, Exeltis, Hungary) and subsequent direct Myo-Ins incubation of spermatozoa before Physiological Intra-Cytoplasmic Sperm Injection (PICSI) procedures in infertile couples due to oligoasthenoteratozoospermia with previous failed PICSI procedures. PATIENTS AND METHODS: We performed a prospective, randomized controlled trial at the Assisted Reproduction Unit of the Kaáli Institute (Gy?r, Hungary). The male partners were randomly assigned to two groups: the first one treated with a myo-Inositol-based supplement (Folandrol?, Exeltis, Hungary) for two months; the second one did not undergo any treatment in the same time range (controls). The semen of the treated group was incubated for 2 h with 2 mg/ml of MI (Andrositol Lab, Lo.Li. Pharma, Rome, Italy) for the PICSI protocol. RESULTS: There was no significant difference for mean female partner age (p = 0.17) and mean previous failed PICSI procedures (p = 0.65) between the two groups. Although there was no significant difference (p = 0.85) regarding the rate of mature oocytes and the fertilization index was significantly higher (p < 0.001) in the treatment group than control group. Also, despite the comparable average number of transferred embryos between the two groups (p = 0.55), in the treatment group there was a significantly higher rate of good quality embryos at day 3 after fertilization (p = 0.001). Finally, 11 pregnancies were obtained only in the treatment group (p = 0.001). CONCLUSIONS: The combination of oral supplementation and semen incubation with MI in oligoasthenoteratozoospermic men could improve PICSI outcomes.
机译：目的：本研究的目的是评估肌醇（Myo-Ins），叶酸，维生素E，L-肉碱，L-精氨酸和硒（Folandrol，Exeltis，匈牙利），以及由于先前的PICSI手术失败而导致的不育夫妇的生理性细胞质内精子注射（PICSI）手术之前，随后进行的直接Myo-Ins孵育。患者与方法：我们在Kaáli研究所（匈牙利吉尔）的辅助生殖部门进行了一项前瞻性，随机对照试验。男性伴侣被随机分为两组：第一组接受基于肌醇的补充剂（Folandrol？，Exeltis，匈牙利）治疗两个月;第二个在相同的时间范围内（对照）未接受任何治疗。将处理过的组的精液与2 mg / ml的MI（Andrositol Lab，Lo.Li. Pharma，Rome，Italy）进行PICSI方案孵育2小时。结果：两组之间的平均女性伴侣年龄（p = 0.17）和先前失败的PICSI程序（p = 0.65）没有显着差异。尽管关于成熟卵母细胞的比率没有显着差异（p = 0.85），并且治疗组的受精指数显着高于对照组（p <0.001）。同样，尽管两组之间的转移胚胎数量相当（p = 0.55），但在治疗组中，受精后第3天的优质胚胎的发生率明显更高（p = 0.001）。最后，仅在治疗组中获得了11次怀孕（p = 0.001）。结论：口服补液和精液与MI混合培养可治疗PICSI的结果。

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