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首页> 外文期刊>European review for medical and pharmacological sciences. >Correlations of degree of coronary artery stenosis with blood lipid, CRP, Hcy, GGT, SCD36 and fibrinogen levels in elderly patients with coronary heart disease
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Correlations of degree of coronary artery stenosis with blood lipid, CRP, Hcy, GGT, SCD36 and fibrinogen levels in elderly patients with coronary heart disease

机译：老年冠心病患者冠状动脉狭窄程度与血脂，CRP，Hcy，GGT，SCD36和纤维蛋白原水平的相关性

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OBJECTIVE: To explore the correlations between the degree of coronary artery stenosis with blood lipid, C-reactive protein (CRP), homocysteine (Hcy), gamma-glutamyl transpeptidase (GGT), soluble cluster determinant 36 (sCD36), and fibrinogen (Fib) levels in elderly patients with coronary heart disease. PATIENTS AND METHODS: The Gensini scores for the coronary artery stenosis were analyzed in patients with single-vessel, double-vessel, and multi-vessel coronary artery diseases in observation group and normal people in control group. Changes in blood lipid-associated parameters, including total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), CRP, Hcy, GGT, sCD36, and Fib were compared between the two groups. The correlations between the Gensini score with changes of the blood-associated parameters, CRP, Hcy, GGT, sCD36, and Fib were analyzed. Finally, univariate and multivariate logistic regression analyses were conducted to determine the risk factors for coronary artery stenosis in elderly patients with coronary heart disease. RESULTS: The Gensini score was significantly higher in coronary heart disease patients with multi-vessel, double-vessel, and single-vessel coronary artery diseases compared with that in normal people (p0.05). The levels of the blood lipid-associated parameters TC, TG, and LDL-C in observation group were substantially higher than those in control group (p0.05), and the level of HDL-C was notably lower than that in control group (p0.05). Subjects in observation group had markedly higher levels of CRP, Hcy, GGT, sCD36, and Fib than control group (p0.05). The Gensini score for the degree of coronary artery stenosis was positively correlated with the levels of the blood lipid-associated parameters TC and TG, CRP, Hcy, GGT, sCD36, and Fib (p0.05) and negatively associated with the level of HDL-C (p0.05). Blood lipid-associated parameters, CRP, Hcy, GGT, sCD36, and Fib were the independent risk factors for coronary artery stenosis in elderly patients with coronary heart disease patients. CONCLUSIONS: The elevations of blood lipid, CRP, Hcy, GGT, sCD36, and Fib levels are closely associated with coronary artery stenosis, and serve as the independent risk factors for coronary artery stenosis.
机译：目的：探讨冠状动脉狭窄程度与血脂，C反应蛋白（CRP），高半胱氨酸（Hcy），γ-谷氨酰转肽酶（GGT），可溶性簇决定簇36（sCD36）和纤维蛋白原（Fib）之间的相关性。 ）老年冠心病患者的水平。方法对观察组和对照组正常人单支，双支和多支冠状动脉疾病患者的冠状动脉狭窄情况进行Gensini评分分析。血脂相关参数的变化，包括总胆固醇（TC），三酰甘油（TG），低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C），CRP，Hcy，GGT，sCD36和Fib在两组之间进行了比较。分析了Gensini评分与血液相关参数，CRP，Hcy，GGT，sCD36和Fib的变化之间的相关性。最后，进行单因素和多因素logistic回归分析，以确定老年冠心病患者冠状动脉狭窄的危险因素。结果：在多支，双支和单支冠状动脉疾病的冠心病患者中，Gensini评分明显高于正常人（p <0.05）。观察组的血脂相关参数TC，TG和LDL-C水平明显高于对照组（p <0.05），而HDL-C水平明显低于对照组（p <0.05）。 p ＜0.05）。观察组受试者的CRP，Hcy，GGT，sCD36和Fib水平明显高于对照组（p <0.05）。冠状动脉狭窄程度的Gensini评分与血脂相关参数TC和TG，CRP，Hcy，GGT，sCD36和Fib的水平呈正相关（p <0.05），与HDL的水平呈负相关-C（p ＜0.05）。血脂相关参数，CRP，Hcy，GGT，sCD36和Fib是老年冠心病患者冠状动脉狭窄的独立危险因素。结论：血脂，CRP，Hcy，GGT，sCD36和Fib的升高与冠状动脉狭窄密切相关，并且是冠状动脉狭窄的独立危险因素。

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