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首页> 外文期刊>European review for medical and pharmacological sciences. >Effects of ulinastatin on inflammatory response and cognitive function after hip arthroplasty for the elderly patients with femoral neck fracture
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Effects of ulinastatin on inflammatory response and cognitive function after hip arthroplasty for the elderly patients with femoral neck fracture

机译：乌司他丁对老年股骨颈骨折患者髋关节置换术后炎症反应和认知功能的影响

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OBJECTIVE: To investigate the effects of ulinastatin on inflammatory response and cognitive function after hip arthroplasty for the elderly patients with femoral neck fracture. PATIENTS AND METHODS: A total of 80 patients with femoral neck fracture receiving hip arthroplasty in our hospital from August 2016 to February 2017 were selected and divided into observation group (n=40) and control group (n=40) using a random number table. The control group was treated with hip arthroplasty and symptomatic and supportive treatment after operation, while the observation group was treated with ulinastatin based on the treatment means of control group. The changes in antioxidant capacities, plasma noradrenaline (NA) and adrenaline (A) levels between the two groups before and after intervention were compared. The changes in neuron-specific enolase (NSE) and plasma S-100B protein levels before intervention and at 48 h after intervention were also compared. Moreover, the changes in mini-mental state examination (MMSE) scores during intervention and the Harris hip scores before intervention and at discharge between the two groups were compared. Finally, the off-bed walking time and postoperative discharge time of the two groups were recorded. RESULTS: After intervention, the levels of malondialdehyde (MDA) and superoxide dismutase (SOD) and the total antioxidant capacity in observation group were significantly superior to those in observation group before intervention and control group after intervention ( p <0.05). After intervention, the levels of NA and A in observation group were lower than those in control group ( p <0.05), and the levels of interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) in observation group were also lower than those in control group ( p <0.05). At 48 h after intervention, the levels of NSE and plasma S-100B protein in observation group were significantly lower than those in observation group before intervention and control group at 48 h after intervention ( p <0.05). At 12 h, 24 h and 48 h after intervention, the MMSE scores of observation group were superior to those of control group in the same period ( p <0.05). After intervention, the Harris hip score of observation group was superior to that of control group before and after intervention ( p <0.05). The postoperative discharge time of observation group was earlier than that of control group ( p <0.05), and the off-bed walking time was also earlier than that of control group ( p <0.05). CONCLUSIONS: The combined application of ulinastatin could effectively reduce the oxidative stress and inflammatory response, improve the neurological functions, and promote the postoperative recovery in the elderly patients with femoral neck fracture after hip arthroplasty.
机译：目的：探讨乌司他丁对老年股骨颈骨折患者髋关节置换术后炎症反应和认知功能的影响。患者与方法：选择2016年8月至2017年2月在我院行髋关节置换术的80例股骨颈骨折患者，采用随机数字表法分为观察组（n = 40）和对照组（n = 40）。 。对照组术后接受髋关节置换术及对症支持治疗，观察组根据对照组的治疗方法给予乌司他丁治疗。比较两组干预前后抗氧化能力，血浆去甲肾上腺素（NA）和肾上腺素（A）水平的变化。还比较了干预前和干预后48小时神经元特异性烯醇化酶（NSE）和血浆S-100B蛋白水平的变化。此外，比较了两组干预期间的迷你精神状态检查（MMSE）得分以及干预之前和出院时的Harris髋关节得分。最后，记录两组的床下行走时间和术后出院时间。结果：干预组观察组丙二醛（MDA），超氧化物歧化酶（SOD）水平和总抗氧化能力明显优于干预组和对照组（p <0.05）。干预后观察组NA，A水平明显低于对照组（p <0.05），白细胞介素1（IL-1），肿瘤坏死因子-α（TNF-α）水平较高，且高于对照组（p <0.05）。观察组的C反应蛋白（hs-CRP）敏感性也低于对照组（p <0.05）。干预后48 h，观察组NSE和血浆S-100B蛋白水平明显低于干预前和对照组（p <0.05）。干预后12 h，24 h和48 h，观察组MMSE评分均优于同期对照组（p <0.05）。干预后，观察组的Harris髋关节评分明显高于对照组（p <0.05）。观察组术后出院时间早于对照组（p <0.05），下床行走时间也早于对照组（p <0.05）。结论：乌司他丁联合应用可有效减轻老年髋关节置换术后股骨颈骨折患者的氧化应激和炎症反应，改善神经功能，促进术后恢复。

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