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首页> 外文期刊>Experimental Animals >Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis)
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Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis)

机译：草酸钾在树sh（tupaia belangeri chinensis）中诱发急性高尿酸血症

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Potassium oxonate, a selectively competitive uricase inhibitor, produced hyperuricemia (HUA) in rodents in a previous study. In this study, we employed the tree shrew as an animal model to study potassium oxonate-induced HUA. The effect of allopurinol (ALLO), a uric acid reducer, was also examined in this model. Potassium oxonate at doses of 5, 20, 40, 60, 80, 100, and 1,000 mg/kg was given intraperitoneally to tree shrews. The results showed that potassium oxonate can effectively increase the levels of uric acid in tree shrews at doses ranging from 40 to 100 mg/kg. Semiquantitative RT-PCR showed that the xanthine dehydrogenase/oxidase (XDH/XO ) mRNA expression level was significantly higher in the liver tissue of tree shrews with high levels of uric acid. There were no changes in serum urea nitrogen, or serum creatinine values. ALLO can significantly decrease serum uric acid levels ( P XDH/XO mRNA expression levels in the liver tissue of tree shrews with HUA. XDH/XO mRNA expression levels did not change in untreated tree shrews. Studies on acute toxicity in the tree shrew did not show any significantly abnormal signs. There were no adverse effects at the macroscopic level up to doses ≤100 mg/kg. Potassium oxonate induced acute HUA in tree shrews at lower doses compared with other animal models. Potassium oxonate-treated tree shrews may be a potential animal model for studying pathogenic mechanism and evaluating a new therapeutic agent for treatment of HUA in humans.
机译：在以前的研究中，选择性竞争性尿酸酶抑制剂草酸钾在啮齿动物中产生高尿酸血症（HUA）。在这项研究中，我们以树sh作为动物模型来研究草酸钾诱导的HUA。在该模型中还检查了尿酸还原剂别嘌呤醇（ALLO）的作用。以5、20、40、60、80、100和1,000 mg / kg的剂量腹膜内给予草sh。结果表明，在40至100 mg / kg的剂量下，草酸钾可以有效提高树sh中的尿酸水平。半定量RT-PCR结果表明，高尿酸水平的树sh的肝脏组织中黄嘌呤脱氢酶/氧化酶（XDH / XO）的mRNA表达水平明显升高。血清尿素氮或肌酐值无变化。 ALLO可以显着降低HUA树liver肝脏组织中的血清尿酸水平（P XDH / XO mRNA表达水平。未经处理的树sh XDH / XO mRNA表达水平不变。表现出任何明显的异常体征。剂量≤100mg / kg时在宏观水平上没有不利影响。与其他动物模型相比，oxonate oxoxate在树sh中诱导的急性HUA剂量更低。潜在的动物模型，用于研究致病机制并评估用于治疗HUA的新型治疗剂。

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