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The kinematic recovery process of rhesus monkeys after spinal cord injury

机译：猕猴脊髓损伤后的运动学恢复过程

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摘要

After incomplete spinal cord injury (SCI), neural circuits may be plastically reconstructed to some degree, resulting in extensive functional locomotor recovery. The present study aimed to observe the post-SCI locomotor recovery of rhesus monkey hindlimbs and compare the recovery degrees of different hindlimb parts, thus revealing the recovery process of locomotor function. Four rhesus monkeys were chosen for thoracic hemisection injury. The hindlimb locomotor performance of these animals was recorded before surgery, as well as 6 and 12 weeks post-lesion. Via principal component analysis, the relevant parameters of the limb endpoint, pelvis, hindlimb segments, and joints were processed and analyzed. Twelve weeks after surgery, partial kinematic recovery was observed at the limb endpoint, shank, foot, and knee joints, and the locomotor performance of the ankle joint even recovered to the pre-lesion level; the elevation angle of the thigh and hip joints showed no obvious recovery. Generally, different parts of a monkey hindlimb had different spontaneous recovery processes; specifically, the closer the part was to the distal end, the more extensive was the locomotor function recovery. Therefore, we speculate that locomotor recovery may be attributed to plastic reconstruction of the motor circuits that are mainly composed of corticospinal tract. This would help to further understand the plasticity of motor circuits after spinal cord injury.
机译：脊髓不完全损伤（SCI）后，神经回路可能在某种程度上被塑性重建，从而导致广泛的功能性运动恢复。本研究旨在观察猕猴后肢SCI运动后的恢复情况，并比较后肢不同部位的恢复程度，从而揭示运动功能的恢复过程。选择四只恒河猴进行胸腔半切损伤。在手术前以及病变后6和12周记录这些动物的后肢运动能力。通过主成分分析，对肢体终点，骨盆，后肢节段和关节的相关参数进行处理和分析。手术后十二周，在肢体终点，小腿，足部和膝关节观察到部分运动学恢复，并且踝关节的运动能力甚至恢复到病变前的水平。大腿和髋关节的仰角没有明显恢复。通常，猴子后肢的不同部分具有不同的自发恢复过程。具体而言，部件越靠近远端，运动功能恢复就越广泛。因此，我们推测运动恢复可以归因于主要由皮质脊髓束组成的运动回路的塑性重建。这将有助于进一步了解脊髓损伤后电动机电路的可塑性。

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