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Immune modulation therapy in the management of bortezomib-induced peripheral neuropathy

机译:免疫调节疗法在硼替佐米引起的周围神经病变的治疗中

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Peripheral neuropathy (PN) is one of the most common side effects of bortezomib therapy. The majority of bortezomib-related PN is a sensory neuropathy of mild to moderate degree, and is reversible after dose reduction or discontinuation. However, occasionally bortezomib-induced neuropathy can be severe and affects motor and/or autonomic nerves, and may be mediated by immune process. The role of immune modulation therapy in the management of bortezomib-induced PN was not well established. Here, we reported a case of bortezomib-induced severe PN that responded well to plasma exchange and steroid treatment.
机译:周围神经病变(PN)是硼替佐米治疗最常见的副作用之一。大多数与硼替佐米相关的PN是轻度至中度的感觉神经病,在减量或停药后可逆。然而,偶尔由硼替佐米引起的神经病可能很严重,并影响运动神经和/或自主神经,并可能由免疫过程介导。尚未确定免疫调节疗法在硼替佐米诱导的PN的管理中的作用。在这里,我们报道了一例硼替佐米引起的严重PN,对血浆置换和类固醇治疗反应良好。

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