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首页> 外文期刊>Experimental Hematology Oncology >CD19: a biomarker for B cell development, lymphoma diagnosis and therapy
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CD19: a biomarker for B cell development, lymphoma diagnosis and therapy

机译：CD19：B细胞发育，淋巴瘤诊断和治疗的生物标志物

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The human CD19 antigen is a 95 kd transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD19 is classified as a type I transmembrane protein, with a single transmembrane domain, a cytoplasmic C-terminus, and extracellular N-terminus. CD19 is a biomarker for normal and neoplastic B cells, as well as follicular dendritic cells. CD19 is critically involved in establishing intrinsic B cell signaling thresholds through modulating both B cell receptor-dependent and independent signaling. CD19 functions as the dominant signaling component of a multimolecular complex on the surface of mature B cells, alongside complement receptor CD21, and the tetraspanin membrane protein CD81 ( TAPA-1 ), as well as CD225. Through study of CD19 transgenic and knockout mouse models, it becomes clear that CD19 plays a critical role in maintaining the balance between humoral, antigen-induced response and tolerance induction. This review also summarized latest clinical development of CD19 antibodies, anti-B4-bR (an immunotoxin conjugate), blinatumomab (BiTE), and SAR3419 (huB4-DM4), a novel antibody-drug conjugate.
机译：人CD19抗原是属于免疫球蛋白超家族的95 kd跨膜糖蛋白。 CD19被归类为I型跨膜蛋白，具有单个跨膜结构域，胞质C末端和细胞外N末端。 CD19是正常和赘生性B细胞以及滤泡树突状细胞的生物标志物。 CD19通过调节B细胞受体依赖性和独立信号传导关键地参与建立固有的B细胞信号传导阈值。 CD19与补体受体CD21，四跨膜蛋白CD81（TAPA-1）和CD225一起，是成熟B细胞表面上多分子复合物的主要信号传导成分。通过研究CD19转基因和基因敲除小鼠模型，可以清楚地看出CD19在维持体液，抗原诱导的反应和耐受诱导之间的平衡中起着关键作用。这篇综述还总结了CD19抗体，抗B4-bR（一种免疫毒素偶联物），blinatumomab（BiTE）和一种新型抗体-药物偶联物SAR3419（huB4-DM4）的最新临床开发。

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