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Impact of tandem autologous stem cell transplantation and response to transplant in the outcome of multiple myeloma

机译：串联自体干细胞移植及其对移植的反应对多发性骨髓瘤的影响

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Background Multiple Myeloma (MM) is the commonest indication for autologous stem cell transplantation (ASCT). Methods We retrospectively analysed data from 85 patients with MM submitted to ASCT in our centre from 2000 to 2010: 132 ASCT were realized, 80 of them as tandem. Results After induction, 17.6% were in complete remission (CR), 41.2% in very good partial remission (VGPR) and 41.2% in partial remission (PR). After transplant 44.7% were in CR, 15.3% in VGPR and 40% in PR. With 22 months (range – 3 to 117 months) of median follow-up, median overall survival (OS) was 43 months and progression-free survival (PFS) 22 months. At 5 years, OS was 45.3% (36.7-53.9%, 95%) and PFS 24.5% (18-31%, 95%). Patients with CR after ASCT had significantly longer PFS as compared to patients with PR (27 vs 7 months; p?=?0.034) but not when compared to patients with VGPR (27 vs 19 months, p?=?0.485). The tandem approach represented an advantage in OS and PFS when compared to only one ASCT (31 vs 19 months - p?=?0.018, and 40 vs 31 - p?=?0.04, respectively). Conclusions Our results highlight the impact of response to transplant in patients PFS and tandem modality showed to carry better PFS and OS then the single transplant.
机译：背景多发性骨髓瘤（MM）是自体干细胞移植（ASCT）的最常见指征。方法回顾性分析我中心2000年至2010年收治的85例MM患者的临床资料：实现132例ASCT，其中80例为串联。结果诱导后，完全缓解（CR）的比例为17.6％，良好部分缓解（VGPR）的比例为41.2％，部分缓解（PR）的比例为41.2％。移植后CR占44.7％，VGPR占15.3％，PR占40％。中位随访期为22个月（范围为3至117个月），中位总生存期（OS）为43个月，无进展生存期（PFS）为22个月。在5年时，OS为45.3％（36.7-53.9％，95％），PFS为24.5％（18-31％，95％）。与PR患者相比，ASCT后CR患者的PFS明显更长（27 vs. 7个月; p = 0.034），而与VGPR患者相比，pFS则更长（27 vs 19个月，p = 0.485）。与仅一个ASCT相比，串联方法在OS和PFS上具有优势（分别为31个月与19个月-p≤0.018，40 vs 31 p = 0.04）。结论我们的结果强调了移植应答对患者PFS的影响，而串联方式显示的PFS和OS优于单次移植。

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