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首页> 外文期刊>Experimental Hematology Oncology >Response of hemorrhagic bullous skin lesions of the breast secondary to primary systemic amyloidosis to a five-drug combination chemotherapy: a case report and review of the literature
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Response of hemorrhagic bullous skin lesions of the breast secondary to primary systemic amyloidosis to a five-drug combination chemotherapy: a case report and review of the literature

机译：继发于原发性系统性淀粉样变性的乳腺出血性大疱性皮肤病变对五药联合化疗的反应：一例并文献复习

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摘要

Two major types of amyloidosis are primary amyloidosis or amyloid light chain amyloidosis and secondary amyloidosis. Although amyloidosis involves a variety of organ systems including skin, the occurrence of bullous skin lesions is rare. Little is known about the mechanism of blister formation. These blisters are often hemorrhagic and typically occur in the oral mucosa. Only a few case reports have described skin involvement in systemic amyloidosis. The manifestation of bullous lesions on the breast in association with primary amyloidosis has not been previously reported. Therefore, we report a case of cutaneous hemorrhagic bullous of the breast secondary to primary systemic amyloidosis, which may be important for medical oncologists to be aware of this uncommon presentation of plasma cell dysrasias. Furthermore, this case only partially responded to the commonly used multiple myeloma-type regimen, the skin lesions responded completely to a five-drug combination chemotherapy regimen, utilizing immunomodulators, liposomal doxorubicin, cyclophosphamide, bortezomib, and dexamethasone, suggesting that a more aggressive modality of chemotherapy may be necessary to treat such cases.
机译：淀粉样变性的两种主要类型是原发性淀粉样变性或淀粉样蛋白轻链淀粉样变性和继发性淀粉样变性。尽管淀粉样变性病涉及包括皮肤在内的多种器官系统，但大疱性皮肤病变的发生很少。关于水疱形成的机制知之甚少。这些水泡通常是出血性的，通常发生在口腔粘膜中。只有少数病例报告描述了皮肤参与系统性淀粉样变性病。先前尚未报道与原发性淀粉样变性相关的乳房大疱性病变的表现。因此，我们报告了一例继发于原发性系统性淀粉样变性的乳房皮肤大出血性出血的病例，这对于医学肿瘤学家了解这种罕见的浆细胞异常症可能很重要。此外，该病例仅对常用的多发性骨髓瘤型治疗方案有部分反应，使用免疫调节剂，脂质体阿霉素，环磷酰胺，硼替佐米和地塞米松对五种药物联合化疗方案的皮肤病变完全有反应，表明这种治疗方式更具侵略性化疗可能需要治疗。

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