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Anesthetic and pathological changes following high doses of ketamine and xylazine in Sprague Dawley rats

机译：大剂量氯胺酮和甲苯噻嗪对Sprague Dawley大鼠的麻醉和病理变化

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The main objective of this study was to compare the effects of ketamine and xylazine in aging rats when coadministered intraperitoneally at high anesthetic doses. Three groups (n=6 rats/group) consisting of rats at 3, 6 and 12 months of age were used. During anesthesia, animals were monitored for heart rate, respiratory frequency, blood oxygen saturation, and rectal temperature. The corneal and paw withdrawal reflex were also examined during anesthesia. During anesthesia, withdrawal and corneal reflexes were absent for progressively longer durations with increasing age. Significant decreases in cardiac and respiratory frequency and, blood oxygen saturation occurred for the 6- and 12-month-old animals. Respiratory frequency and blood oxygen saturation returned to normal at the end of the anesthesia; however, the significant decrease in cardiac frequency persisted in the 6- and 12-month-old animals. Rectal temperature was decreased significantly only in the 3-month-old animals. Pulmonary edema and effusion occurred in 50% of the 12-month-old animals. In conclusion, if ketamine-xylazine are used for anesthesia, the doses should be optimized for the age of the subjects prior to initiation of the research project.
机译：这项研究的主要目的是比较在高麻醉剂量腹膜内共同给药时，氯胺酮和甲苯噻嗪对衰老大鼠的影响。使用由3、6和12个月大的大鼠组成的三组（n ＝ 6只大鼠/组）。在麻醉期间，监测动物的心率，呼吸频率，血氧饱和度和直肠温度。麻醉期间还检查了角膜和爪的退缩反射。在麻醉过程中，随着年龄的增长，停药和角膜反射消失的时间越来越长。 6个月和12个月大的动物的心脏和呼吸频率显着降低，并且血氧饱和度降低。麻醉结束时呼吸频率和血氧饱和度恢复正常。然而，在6个月和12个月大的动物中，心脏频率显着下降。直肠温度仅在3个月大的动物中显着降低。在12月龄的动物中，有50％发生了肺水肿和积液。总之，如果将氯胺酮-甲苯噻嗪用于麻醉，则应在启动研究项目之前针对受试者的年龄优化剂量。

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