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Swine model of in-stent stenosis in the iliac artery evaluating the serial time course

机译：evaluating动脉支架内狭窄的猪模型评估连续时间过程

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The aim of this study was to propose a new animal model evaluating the serial time course of in-stent stenosis by repeated carotid artery catheterization in the same animal. 16 bare-metal stents were implanted in the normal external and internal iliac artery of 8 miniature pigs. Repeated measurements were performed in the same animal every 2 weeks for 12 weeks through carotid artery catheterization. The time course and peak neointimal proliferation were evaluated by intravascular ultrasound. Health of all animals was assessed by clinical and hematological examinations. As a result, 7 times of carotid artery catheterization was performed per pig, but all animals remained healthy without both any complications and hematological inflammatory abnormalities. The time course of neointimal proliferation of each stent was observed from the stage of hyperplasia to partial regression. The peak neointimal proliferation varied from 6 to 12 weeks despite implantation of identical stents using the same deployment method. In conclusion, repeated carotid artery catheterization to the same animal is feasible without animal health deterioration. This model should be useful to evaluate the time course of neointimal proliferation after stent deployment in preclinical study.
机译：这项研究的目的是提出一种新的动物模型，该模型通过在同一只动物中反复进行颈动脉导管插入术来评估支架内狭窄的连续时间进程。在8头小型猪的正常external内外动脉中植入了16个裸金属支架。通过颈动脉导管插入，每2周对同一个动物进行一次重复测量，持续12周。通过血管内超声评估时间进程和新内膜增殖高峰。通过临床和血液学检查评估所有动物的健康。结果，每头猪进行了7次颈动脉导管插入术，但所有动物均保持健康，没有任何并发​​症和血液学炎症异常。从增生阶段到部分消退阶段，观察每个支架的新内膜增生的时间过程。尽管使用相同的展开方法植入相同的支架，但新内膜的峰值增殖在6至12周内变化。总之，在不损害动物健康的前提下，对同一只动物重复进行颈动脉导管插入术是可行的。该模型应可用于评估临床前研究中支架部署后新内膜增生的时间过程。

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