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首页> 外文期刊>Eukaryotic cell >Tcc1p, a Novel Protein Containing the Tetratricopeptide Repeat Motif, Interacts with Tup1p To Regulate Morphological Transition and Virulence in Candida albicans
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Tcc1p, a Novel Protein Containing the Tetratricopeptide Repeat Motif, Interacts with Tup1p To Regulate Morphological Transition and Virulence in Candida albicans

机译：Tcc1p，一种包含四肽重复序列的新型蛋白质，与Tup1p相互作用以调节白色念珠菌的形态转化和毒力。

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摘要

The transcriptional factor CaTup1p represses many genes involved in intracellular processes, including the yeast-hypha transition, in the human fungal pathogen Candida albicans. Using tandem affinity purification technology, we identified a novel protein that interacts with CaTup1p, named Tcc1p (Tup1p complex component). Tcc1p is a C. albicans-specific protein with a 736-amino-acid polypeptide with four tetratricopeptide repeat (TPR) motifs in the N-terminal portion. Tcc1p formed a protein complex with CaTup1p via the TPR domain of Tcc1p, independently of CaSsn6p-CaTup1p The tcc1Δ disruptant showed filamentous growth under conditions inducing the yeast form, as is true of the Catup1Δ mutant. Consistent with this result, the common set of hypha-specific genes was negatively regulated by both TCC1 and CaTUP1. These observations will provide new insights into CaTup1p-dependent transcriptional gene regulation in C. albicans.
机译：转录因子CaTup1p抑制了人类真菌病原体白色念珠菌中许多涉及细胞内过程的基因，包括酵母菌-菌丝的转变。使用串联亲和纯化技术，我们鉴定了一种与CaTup1p相互作用的新型蛋白质，名为Tcc1p（Tup1p复合物）。 Tcc1p是 C。白蛋白特异蛋白，具有736个氨基酸的多肽，在其N端部分具有四个四肽重复序列（TPR）。 Tcc1p经由Tcc1p的TPR结构域与CaTup1p形成蛋白质复合物，独立于CaSsn6p-CaTup1p。tcc1Δ破坏剂在诱导酵母形式的条件下显示丝状生长，这与Ca tup1 < / em>Δ突变体。与该结果一致， TCC1 和Ca TUP1 对共同的菌丝特异性基因均负调控。这些观察将提供对 C中CaTup1p依赖性转录基因调控的新见解。白色的。

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