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Microbiological Quality Assessment of Laboratory Mice in Korea and Recommendations for Quality Improvement

机译：韩国实验室小鼠的微生物质量评估和质量改进建议

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Regular monitoring of commercial laboratory rodents and institutional research animal residents is essential for microbiological quality control programs. The objective of our study was to investigate the recent prevalence of infectious pathogens in laboratory mice from eight experimental animal vendors and 56 institutional animal facilities in Korea. Our investigation was conducted in 2006-2007. Specific Pathogen Free (SPF) mice from four commercial breeders were clean according to serological, bacteriological, parasitological, and histopathological examination results. However, mice from one intermediate vendor that distributed SPF animals from main commercial vendors to local districts had Syphacia obvelata and Mycoptes musculinus infections. Additionally, mice from conventional animal breeders were highly contaminated. Among the 56 institutional animal facilities, mouse hepatitis virus (MHV), Sendai virus and Mycoplasma pulmonis positive results were obtained in 23.2, 8.9, and 1.8% of animals tested, respectively. These results indicate that quarantine and eradication efforts of infectious pathogens in these facilities are sub-optimal and need to be improved. The use of commercial conventional mice for research should be eliminated and appropriate vendor selection as well as thorough quarantine before releasing animals into a facility are needed. Finally we suggest qualified veterinary experts are needed at each animal facility to ensure an adequate health surveillance program.
机译：定期监测商业实验室啮齿动物和机构研究动物的居民对于微生物质量控制计划至关重要。我们研究的目的是调查来自韩国的8家实验动物供应商和56家机构动物设施的实验小鼠中传染病原体的流行情况。我们的调查是在2006-2007年进行的。根据血清学，细菌学，寄生虫学和组织病理学检查的结果，来自四个商业饲养者的无特定病原体（SPF）小鼠是干净的。但是，从一家将主要商业供应商的SPF动物分发到当地地区的中间供应商的小鼠感染了Syphacia obvelata和Mycoptes musculinus感染。另外，来自常规动物育种者的小鼠被高度污染。在56家机构动物设施中，分别有23.2％，8.9％和1.8％的动物获得了小鼠肝炎病毒（MHV），仙台病毒和肺炎支原体的阳性结果。这些结果表明，在这些设施中对传染性病原体的隔离和根除工作不是最理想的，需要改进。应当避免使用商业常规小鼠进行研究，并且需要适当的供应商选择以及彻底隔离，然后再将动物释放到设施中。最后，我们建议每个动物设施都需要合格的兽医专家，以确保有足够的健康监督程序。

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