...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Gene Therapy and Molecular Biology >Signaling pathways and polyomavirus oncoproteins:Importance in malignant transformation
【24h】

Signaling pathways and polyomavirus oncoproteins:Importance in malignant transformation

机译：信号通路和多瘤病毒癌蛋白：恶性转化的重要性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Treatment of a particular cancer, whether by gene therapy or by small molecule inhibitors, is predicated upon a knowledge of the signal transduction pathways that became dysregulated as the tumor developed and cells underwent malignant transformation. Usually cancer is thought of as a disease that progresses through the gradual accumulation of multiple successive genetic “hits” leading from normal cells to fully malignant metastatic tumors in a fashion such as that described for the colorectal adenoma-carcinoma sequence. These hits include mutations that activate oncogenes, knockouts of anti-oncogenes (tumor suppressors) and events that increase mutation rates or destabilize the genome. Polyomaviruses are small DNA viruses that encode proteins that promote cell transformation in culture, induce tumors in experimental animals and have been found in association with some human cancers. The small genome size of the polyomaviruses means that a few proteins must perform many tasks. There is evidence that these multifunctional viral proteins can provide several “hits” at once to cells and thus circumvent certain steps that are necessary for malignant transformation during non-viral tumorigenesis. In this review, the biological and pathological properties of polyomavirus proteins are discussed. The relevance of these is underscored by the growing evidence for the involvement of polyomaviruses in some human cancers. Polyomavirus gene-specific therapeutic strategies might be considered in these cancers since ablation of the function of viral oncoproteins would be expected to reverse multiple molecular events involved in malignant transformation.
机译：特定的癌症，无论是通过基因治疗还是通过小分子抑制剂进行治疗，都是基于对信号转导途径的了解，该信号转导途径随着肿瘤的发展和细胞进行恶性转化而变得失调。通常，癌症被认为是一种疾病，它是通过从正常细胞到完全恶性转移性肿瘤的多个连续遗传“打击”逐渐积累而发展起来的，例如针对大肠腺瘤-癌序列所描述的方式。这些命中包括激活癌基因的突变，抗癌基因（肿瘤抑制剂）的敲除以及增加突变率或破坏基因组稳定性的事件。多瘤病毒是小的DNA病毒，其编码的蛋白质可促进培养物中的细胞转化，诱导实验动物的肿瘤，并已发现与某些人类癌症有关。多瘤病毒的基因组很小，这意味着一些蛋白质必须执行许多任务。有证据表明，这些多功能病毒蛋白可以一次向细胞提供多个“打击”，从而规避了非病毒肿瘤发生过程中恶性转化所必需的某些步骤。在这篇综述中，讨论了多瘤病毒蛋白的生物学和病理学特性。越来越多的证据表明多瘤病毒与某些人类癌症有关，从而突出了这些问题的相关性。在这些癌症中可考虑使用多瘤病毒基因特异性治疗策略，因为预计病毒癌蛋白功能的消融可逆转参与恶性转化的多种分子事件。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号