Targeting of cancer gene therapy with antibodies ortheir genes against tumor-associated antigens

Dr. Masahide Kuroki

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Targeting of cancer gene therapy with antibodies ortheir genes against tumor-associated antigens

机译：用抗肿瘤相关抗原的抗体或其基因靶向癌症基因治疗

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Gene therapy is expected to play a major role in future cancer treatment. Actually various therapeutic genes have shown promise for tumor cell killing. However, successful gene therapy depends on the development of efficient and targeted gene transfer vectors. This overview summarizes the current use of anti-tumor-associated antigen (TAA) antibodies in cancer gene therapy. Current data suggest that antibodies or their genes against TAAs can be used for targeting viral vectors for cancer gene therapy.

机译：基因治疗有望在未来的癌症治疗中发挥重要作用。实际上，各种治疗基因已显示出杀死肿瘤细胞的希望。然而，成功的基因治疗取决于有效和靶向的基因转移载体的开发。该概述总结了抗肿瘤相关抗原（TAA）抗体在癌症基因治疗中的当前用途。当前数据表明针对TAA的抗体或其基因可用于靶向用于癌症基因治疗的病毒载体。

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《Gene Therapy and Molecular Biology》 |2005年第2期|共6页
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Dr. Masahide Kuroki;
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中图分类基础医学;
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专利

1. Tumor-targeting of viral vectors for cancer gene therapy by using antibodies or their genes against tumor-associated antigens. [J] . Kuroki M, Kuroki M, Shibaguchi H, Anticancer Research: International Journal of Cancer Research and Treatment . 2004,第5C期

机译：通过使用针对肿瘤相关抗原的抗体或其基因，对用于癌症基因治疗的病毒载体进行肿瘤靶向。
2. Immunotherapy and gene therapy of cancer using antibodies or their genes against tumor-associated antigens. [J] . Kuroki M, Shibaguchi H, Imakiire T, Anticancer Research: International Journal of Cancer Research and Treatment . 2003,第6Appa期

机译：使用针对肿瘤相关抗原的抗体或其基因对癌症进行免疫治疗和基因治疗。
3. The boosting effect of co-transduction with cytokine genes on cancer vaccine therapy using genetically modified dendritic cells expressing tumor-associated antigen [J] . Toshiyasu Ojima, Makoto Iwahashi, Masaki Nakamura, International journal of oncology . 2006,第4期

机译：用遗传修饰的树突细胞表达肿瘤相关抗原的癌症疫苗治疗细胞因子基因的增强效应
4. GENERATION OF CANINE SINGLE CHAIN ANTIBODY LIBRARIES FOR IN VIVO TARGETING OF TUMOR ASSOCIATED ANTIGENS [C] . Nicola J Mason, Koranda Wallace, Laura Pell Annual conference of the Veterinary Cancer Society . 2008

机译：犬单链抗体文库的生成体内靶向肿瘤相关抗原
5. Targeted siRNA Delivery Strategy with Water-in-Oil-in-Water Multiple Emulsion for Modulation of Tumor-Associated Macrophage Polarity in Immunotherapy of Cancer [D] . Oka, Adwait 2015

机译：有针对性的siRNA传递策略与水包油中水多乳液调节肿瘤相关巨噬细胞极性在免疫疗法中的癌症。
6. Conditions of tumor-associated antigens as a proper target for therapeutic antibodies against solid cancers [O] . Y Kurosawa 2011

机译：肿瘤相关抗原作为针对实体癌的治疗性抗体的适当靶标的条件
7. Antibody-mediated endocytosis of G250 tumor-associated antigen allows targeted gene transfer to human renal cell carcinoma in vitro [O] . A Dürrbach, E Angevin, P Poncet, 1999

机译：抗体介导的G250肿瘤相关抗原的内吞作用允许靶向基因转移到人类肾细胞癌体外
8. Mechanism of Action of Prostate Stem Cell Antigen Targeted Antibody Therapy and Its Relevance to Clinical Application in Prostate Cancer [R] . Reiter, R. 2009

机译：前列腺干细胞抗原靶向抗体治疗的作用机制及其与前列腺癌临床应用的相关性

Targeting of cancer gene therapy with antibodies ortheir genes against tumor-associated antigens

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