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首页> 外文期刊>Experimental diabetes research >Topical Application of Sadat-Habdan Mesenchymal Stimulating Peptide (SHMSP) Accelerates Wound Healing in Diabetic Rabbits
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Topical Application of Sadat-Habdan Mesenchymal Stimulating Peptide (SHMSP) Accelerates Wound Healing in Diabetic Rabbits

机译：Sadat-Habdan间充质刺激肽（SHMSP）的局部应用可加速糖尿病兔的伤口愈合

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Objective. Diminished wound healing is a common problem in diabetic patients due to diminished angiogenesis. SHMSP was found to promote angiogenesis. The present study was carried out to examine the effect of this peptide in healing of wounds in diabetic rabbits.Materials and Methods. Twenty male New Zealand rabbits were used in this study. Diabetes mellitus was induced and the rabbits were randomly divided into two equal groups: control group and peptide group. A-full thickness punch biopsy was made to create a wound of about 10 mm on the right ears of all rabbits. Every day, the wound was cleaned with saline in control groups. In the peptide group, 15 mg of SHMSP was applied after cleaning. On day 15th, all animals were sacrificed, and the wounds were excised with a rim of 5 mm of normal surrounding tissue. Histo-pathological assessment of wound healing, inflammatory cell infiltration, blood vessel proliferation, and collagen deposition was performed.Results. There were no deaths among the groups. There was significant increase in wound healing, blood vessel proliferation and collagen deposition, and significant decrease in inflammatory cell infiltration in the peptide group compared to the control group.Conclusion. Topical application of SHMSP improves wound healing in diabetic rabbits.
机译：目的。由于血管生成减少，伤口愈合减弱是糖尿病患者的常见问题。发现SHMSP促进血管生成。本研究旨在探讨该肽在糖尿病兔伤口愈合中的作用。材料与方法。在该研究中使用了20只雄性新西兰兔。诱导糖尿病，将兔子随机分为两组，即对照组和肽组。进行全厚度打孔活检，以在所有兔子的右耳上造成约10mm的伤口。每天在对照组中用盐水清洗伤口。在肽组中，清洗后使用15 mg的SHMSP。在第15天，处死所有动物，并用正常周围组织5毫米的边缘切除伤口。对伤口愈合，炎症细胞浸润，血管增生和胶原沉积进行了组织病理学评估。各组之间没有死亡。与对照组相比，肽组的伤口愈合，血管增生和胶原沉积显着增加，炎性细胞浸润显着减少。 SHMSP的局部应用可改善糖尿病兔子的伤口愈合。

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