• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Experimental diabetes research >The Pathophysiology of HIV-/HAART-Related Metabolic Syndrome Leading to Cardiovascular Disorders: The Emerging Role of Adipokines
【24h】

The Pathophysiology of HIV-/HAART-Related Metabolic Syndrome Leading to Cardiovascular Disorders: The Emerging Role of Adipokines

机译：HIV / HAART相关代谢综合征导致心血管疾病的病理生理学：脂肪因子的新兴作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Individuals infected with human immunodeficiency virus (HIV) frequently demonstrate metabolic syndrome (MS) associated with increased incidence of cardiovascular disorders. Characteristics of HIV infection, such as immunodeficiency, viral load, and duration of the disease, in addition to the highly active antiretroviral therapy (HAART) have been suggested to induce MS in these patients. It is well documented that MS involves a number of traditional cardiovascular risk factors, like glucose, lipids, and arterial blood pressure abnormalities, leading to extensive atherogenic arterial wall changes. Nevertheless, the above traditional cardiovascular risk factors merely explain the exacerbated cardiovascular risk in MS. Nowadays, the adipose-tissue derivatives, known as adipokines, have been suggested to contribute to chronic inflammation and the MS-related cardiovascular disease. In view of a novel understanding on how adipokines affect the pathogenesis of HIV/HAART-related MS and cardiovascular complications, this paper focuses on the interaction of the metabolic pathways and the potential cardiovascular consequences. Based on the current literature, we suggest adipokines to have a role in the pathogenesis of the HIV/HAART-related MS. It is crucial to understand the pathophysiology of the HIV/HAART-related MS and apply therapeutic strategies in order to reduce cardiovascular risk in HIV patients.
机译：感染人类免疫缺陷病毒（HIV）的个体经常表现出与心血管疾病发生率增加相关的代谢综合征（MS）。已建议除了高活性抗逆转录病毒疗法（HAART）外，HIV感染的特征（如免疫缺陷，病毒载量和疾病持续时间）可诱发这些患者的MS。大量文献证明，MS涉及许多传统的心血管危险因素，例如葡萄糖，脂质和动脉血压异常，导致广泛的动脉粥样硬化动脉壁改变。然而，上述传统的心血管危险因素仅解释了MS中加剧的心血管危险。如今，已提出被称为脂肪因子的脂肪组织衍生物有助于慢性炎症和与MS相关的心血管疾病。鉴于对脂肪因子如何影响HIV / HAART相关MS的发病机制和心血管并发症的新颖理解，本文着重研究代谢途径与潜在心血管后果的相互作用。根据目前的文献，我们建议脂肪因子在HIV / HAART相关MS的发病机制中起作用。了解HIV / HAART相关MS的病理生理并应用治疗策略以降低HIV患者的心血管风险至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号