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Aerobic bacteria associated with symptomatic gallstone disease and their antimicrobial susceptibility

机译:与症状性胆结石病相关的需氧细菌及其抗菌药敏性

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Introduction: Gallstone disease is a major health problem throughout the world. Apart from surgery prompt administration of appropriate antibiotics to control the biliary tract infection is important. Objective: Illustrate the bacteriology of gallstone disease. Design: The bile stones and bile of patients with symptomatic gallbladder disease, who underwent cholecystectomy, over a period of one year, were cultured aerobically in blood agar and MacConkey agar. Enrichment was not done, as it was not indicated in previous studies. The isolates were identified according to standard microbiological procedures and were tested for their sensitivity pattern. Settings: Department of Microbiology, University of Sri Jayawardenapura and Colombo South Teaching Hospital, Kalubowila, Sri Lanka. Results: Twenty percent of the patients were positive for bacteria in either bile or stones. Escherichia coli (40%), Klebsiella spp (35%) and Enterobacter spp (20%) were the commonest isolates. Ninety one percent of all isolates were Coliforms. Conclusions: We recommend obtaining of cultures of bile and gallstones at the time of cholecystectomy so that appropriate antibiotics can be administered in the event of a positive culture to prevent serious complications like gram negative septicaemia. According to our results, co-amoxiclav in combination with an aminoglycoside for aerobic bacteria along with metronidazole to cover anaerobic bacteria is an empirical therapy that can be used before the results of bacteriological cultures. Cefotaxime or imipenem can be used for aerobic bacteria as an alternative treatment. ? doi: 10.4038/gmj.v11i1.1110 Galle Medical Journal Vol.11(1) 2006 9-13
机译:简介:胆结石病是全世界的主要健康问题。除手术外,及时给予适当的抗生素以控制胆道感染也很重要。目的:阐明胆结石病的细菌学。设计:将接受胆囊切除术的有症状胆囊疾病患者的胆结石和胆汁在一年的时间内在血琼脂和MacConkey琼脂上进行有氧培养。富集没有完成,因为以前的研究没有指出。根据标准微生物程序鉴定分离物,并测试其敏感性模式。地点:斯里贾亚瓦德纳普拉大学微生物科和斯里兰卡卡卢博维拉的科伦坡南方教学医院。结果:20%的患者胆汁或结石细菌阳性。大肠杆菌(40%),克雷伯菌(3%)和肠杆菌(20%)是最常见的分离株。所有分离株中有91%是大肠菌。结论:我们建议在进行胆囊切除术时获得胆汁和胆结石的培养物,以便在培养物呈阳性的情况下可以施用适当的抗生素,以防止严重的并发症如革兰氏阴性败血病。根据我们的研究结果,共氧合阿昔洛韦与氨基糖苷类结合用于需氧细菌以及甲硝唑以覆盖厌氧菌是一种经验疗法,可以在细菌培养结果之前使用。头孢噻肟或亚胺培南可用于需氧细菌的替代治疗。 ? doi:10.4038 / gmj.v11i1.1110 Galle医学杂志Vol.11(1)2006 9-13

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